全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Resection and Reconstruction of Maxillary Class IIIc Defect in a Case of Adenoid Cystic Carcinoma: Cost-Sensitive Technique without Microvascular Grafts

DOI: 10.1155/2013/865010

Full-Text   Cite this paper   Add to My Lib

Abstract:

ACC is a rare malignant tumor that affects most commonly the major and minor salivary glands and rarely the paranasal sinuses, lacrimal gland, larynx, ear, vulva, and so forth. The maxillary sinus when affected is considered having a poor prognosis due to delayed diagnosis and delayed treatment credited to its slow spread, late symptoms, and complex anatomy which hampers surgical resection. The expressions of tumor markers too have a significant role in determining the prognosis. The treatment of choice consists of wide radical resection of the tumor followed by radiotherapy. Rehabilitation options in cases with huge maxillary defects still need further exploration. 1. Introduction Adenoid cystic carcinoma (ACC) is a rare malignancy, accounting for less than 5% of all head and neck cancers [1]. ACC arises within secretory glands, most commonly the major and minor salivary glands of the head and neck. ACC can also originate from sites other than the salivary glands, such as the lacrimal gland, external ear, paranasal sinuses, larynx, tracheobronchial tree, breast, and vulva, and such ACC is called nonsalivary ACC [2]. ACC of the maxillary antrum is frequently overlooked, and therefore, patients with this tumour usually come at an advanced stage making radical resection unlikely. Difficult access and anticipated surgical morbidity are other major barriers in treatment. Biological markers Ki-67, cyclineD1, E-cadherin, and p16 also have an important impact on prognosis [3, 4]. Older age, advanced stage, positive resection margin, high histological grade, and higher expression of Ki-67 were also associated with poor outcomes. 2. Case Report A 40-year-old male patient reported to the Department of Oral and Maxillofacial Surgery with a chief complaint of painless swelling on the left side of the face and obstruction in nasal breathing since 3 years. The swelling was slow growing, painless, and persistent in growth. There was no reduction in size of the swelling since the patient had noticed it. Personal history was negative for any detrimental habits. On extra oral examination, a large swelling was seen on left side of face, extending superoinferiorly from medial canthus of left eye till left commissure of lips and anteroposteriorly from the left lateral surface of nasal septal cartilage till 4?cm short of tragus of left ear. On nasal examination, there was severe deviation of nasal septum seen towards the right side, along with thick polyp-like mucosal obstruction in the left nostril. On eye examination, the left eye was virtually closed and raised due to the

References

[1]  D. R. Gomez, B. S. Hoppe, S. L. Wolden et al., “Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience,” International Journal of Radiation Oncology Biology Physics, vol. 70, no. 5, pp. 1365–1372, 2008.
[2]  A. G. Lee, P. H. Phillips, N. J. Newman et al., “Neuro-ophthalmologic manifestations of adenoid cystic carcinoma,” Journal of Neuro-Ophthalmology, vol. 17, no. 3, pp. 183–188, 1997.
[3]  K. Triantafillidou, J. Dimitrakopoulos, F. Iordanidis, and D. Koufogiannis, “Management of adenoid cystic carcinoma of minor salivary glands,” Journal of Oral and Maxillofacial Surgery, vol. 64, no. 7, pp. 1114–1120, 2006.
[4]  L. Norberg-Spaak, I. Dardick, and T. Ledin, “Adenoid cystic carcinoma: use of cell proliferation. BCL-2 expression, histologic grade, and clinical stage as predictors of clinical outcome,” Head and Neck, vol. 22, no. 5, pp. 489–497, 2000.
[5]  L. L. Myers, B. Nussenbaum, C. R. Bradford, T. N. Teknos, R. M. Esclamado, and G. T. Wolf, “Paranasal sinus malignancies: an 18-year single institution experience,” Laryngoscope, vol. 112, no. 11, pp. 1964–1969, 2002.
[6]  P. Dulguerov, M. S. Jacobsen, A. S. Allal, W. Lehmann, and T. Calcaterra, “Nasal and paranasal sinus carcinoma: are we making progress? A series of 220 patients and a systematic review,” Cancer, vol. 92, no. 12, pp. 3012–3029, 2001.
[7]  T. Norlander, J. Fr?din, C. Silfversw?rd, and A. ?nggard, “Decreasing incidence of malignant tumors of the paranasal sinuses in Sweden: an analysis of 141 consecutive cases at Karolinska Hospital from 1960 to 1980,” Annals of Otology, Rhinology and Laryngology, vol. 112, no. 3, pp. 236–241, 2003.
[8]  J. N. Waldron, O. 'Sullivan B, P. Gullane et al., “Carcinoma of the maxillary antrum: a retrospective analysis of 110 cases,” Radiotherapy and Oncology, vol. 57, no. 2, pp. 167–173, 2000.
[9]  L. Tran, J. Sidrys, D. Horton, A. Sadeghi, and R. G. Parker, “Malignant salivary gland tumors of the paranasal sinuses and nasal cavity. The UCLA experiences,” The American Journal of Clinical Oncology, vol. 12, no. 5, pp. 387–392, 1989.
[10]  N. Bhattacharyya, “Survival and staging characteristics for non-squamous cell malignancies of the maxillary sinus,” Archives of Otolaryngology—Head and Neck Surgery, vol. 129, no. 3, pp. 334–337, 2003.
[11]  J. Brown, “Maxillary reconstruction,” Indian Journal of Plastic Surgery, vol. 40, no. 12, pp. S35–S43, 2007.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133