Purpose. To examine the effects of acupuncture on sleep quality and on emotional measures among patients with schizophrenia. Methods. Twenty patients with schizophrenia participated in the study. The study comprised a seven-day running-in no-treatment period, followed by an eight-week experimental period. During the experimental period, participants were treated with acupuncture twice a week. During the first week (no-treatment period) and the last week of the experimental period, participants filled out a broad spectrum of questionnaires and their sleep was continuously monitored by wrist actigraph. Results. A paired-sample t-test was conducted comparing objective and subjective sleep parameters manifested by participants before and after sequential acupuncture treatment. A significant effect of acupuncture treatment was observed for seven objective sleep variables: sleep onset latency, sleep percentage, mean activity level, wake time after sleep onset, mean number of wake episodes, mean wake episode and longest wake episode. However, no significant effects of acupuncture treatment were found for subjective sleep measures. Likewise, the results indicate that acupuncture treatment improved psychopathology levels and emotional measures, that is, depression level and anxiety level. Conclusions. Overall, the findings of this pilot study suggest that acupuncture has beneficial effects as a treatment for insomnia and psychopathology symptoms among patients with schizophrenia. 1. Introduction Schizophrenia is a mental disorder involving disturbances in basic mental functions, such as emotions, cognition, perception, and other aspects of behavior [1–3]. The clinical picture of schizophrenia is characterized by a mixture of two main categories of core symptoms: positive symptoms (i.e., delusions and hallucinations) and negative symptoms (i.e., apathy, flat affect, and lack of functioning) [4–6]. Its lifetime prevalence is about 1%, with equal distribution between men and women [4]. Schizophrenia is known to be one of the most debilitating and distressful mental disorders, and during its course the disease often deteriorates and becomes chronic [7–9]. Schizophrenia is responsible for tremendous emotional and economic burdens on patients, their families, and society as a whole [8, 10]. Further, it may be valuable to consider schizophrenia as a multidimensional disorder that includes several different domains, among them clinical, neurocognitive, occupational, familial, and societal, and perhaps most important subjective well-being and positive feelings [11].
References
[1]
R. W. Heinrichs and K. K. Zakzanis, “Neurocognitive deficit in schizophrenia: a quantitative review of the evidence,” Neuropsychology, vol. 12, no. 3, pp. 426–445, 1998.
[2]
A. I. Green, M. S. Salomon, M. J. Brenner, and K. Rawlins, “Treatment of schizophrenia and comorbid substance use disorder,” CNS and Neurological Disorders—Drug Targets, vol. 1, no. 2, pp. 129–139, 2002.
[3]
P. F. Buckley, B. J. Miller, D. S. Lehrer, and D. J. Castle, “Psychiatric comorbidities and schizophrenia,” Schizophrenia Bulletin, vol. 35, no. 2, pp. 383–402, 2009.
[4]
American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Press, Washington, DC, USA, 4th edition, 1994.
[5]
J. S. Brekke, J. D. Long, N. Nesbitt, and E. Sobel, “The impact of service characteristics on functional outcomes from community support programs for persons with schizophrenia: a growth curve analysis,” Journal of Consulting and Clinical Psychology, vol. 65, no. 3, pp. 464–475, 1997.
[6]
R. Hunter and S. Barry, “Negative symptoms and psychosocial functioning in schizophrenia: neglected but important targets for treatment,” European Psychiatry, vol. 27, no. 6, pp. 432–436, 2012.
[7]
E. Y. H. Chen, C. L. Kwok, J. W. Y. Au, R. Y. L. Chen, and B. S. T. Lau, “Progressive deterioration of soft neurological signs in chronic schizophrenic patients,” Acta Psychiatrica Scandinavica, vol. 102, no. 5, pp. 342–349, 2000.
[8]
A. Oni-Orisan, L. V. Kristiansen, V. Haroutunian, J. H. Meador-Woodruff, and R. E. McCullumsmith, “Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia,” Biological Psychiatry, vol. 63, no. 8, pp. 766–775, 2008.
[9]
G. Venkatasubramanian and M. S. Keshavan, “Early intervention in psychosis: perspectives on Asian studies,” Asian Journal of Psychiatry, vol. 5, no. 1, pp. 1–2, 2012.
[10]
K. T. Mueser, D. P. Valentiner, and J. Agresta, “Coping with negative symptoms of schizophrenia: patient and family perspectives,” Schizophrenia Bulletin, vol. 23, no. 2, pp. 329–339, 1997.
[11]
J. P. Lindenmayer, R. Bernstein-Hyman, and S. Grochowski, “Five-factor model of schizophrenia,” Journal of Nervous and Mental Disease, vol. 182, no. 11, pp. 631–638, 1994.
[12]
J. M. Monti and D. Monti, “Sleep in schizophrenia patients and the effects of antipsychotic drugs,” Sleep Medicine Reviews, vol. 8, no. 2, pp. 133–148, 2004.
[13]
S. Zisook, M. Nyer, J. Kasckow, S. Golshan, D. Lehman, and L. Montross, “Depressive symptom patterns in patients with chronic schizophrenia and subsyndromal depression,” Schizophrenia Research, vol. 86, no. 1-3, pp. 226–233, 2006.
[14]
K. Wulff, D. Dijk, B. Middleton, R. G. Foster, and E. M. Joyce, “Sleep and circadian rhythm disruption in schizophrenia,” The British Journal of Psychiatry, vol. 200, no. 4, pp. 308–316, 2012.
[15]
D. Riemann, “Insomnia and comorbid psychiatric disorders,” Sleep Medicine, vol. 8, supplement 4, pp. S15–S20, 2007.
[16]
W. Szelenberger and C. Soldatos, “Sleep disorders in psychiatric practice,” World Psychiatry, vol. 4, no. 3, pp. 186–190, 2005.
[17]
J. M. Kane and Z. A. Sharif, “Atypical antipsychotics: sedation versus efficacy,” Journal of Clinical Psychiatry, vol. 69, supplement 1, pp. 18–31, 2008.
[18]
J. Poulin, A. M. Daoust, G. Forest, E. Stip, and R. Godbout, “Sleep architecture and its clinical correlates in first episode and neuroleptic-naive patients with schizophrenia,” Schizophrenia Research, vol. 62, no. 1-2, pp. 147–153, 2003.
[19]
S. Cohrs, “Sleep disturbances in patients with schizophrenia: impact and effect of antipsychotics,” CNS Drugs, vol. 22, no. 11, pp. 939–962, 2008.
[20]
J. Kantrowitz, L. Citrome, and D. Javitt, “GABAB receptors, schizophrenia and sleep dysfunction: a review of the relationship and its potential clinical and therapeutic implications,” CNS Drugs, vol. 23, no. 8, pp. 681–691, 2009.
[21]
J. A. Costa e Silva, “Sleep disorders in psychiatry,” Metabolism: Clinical and Experimental, vol. 55, supplement 2, pp. S40–S44, 2006.
[22]
American Sleep Disorders Association, International Classification of Sleep Disorders, Revised: Diagnostic and Coding Manual, American Sleep Disorders Association, Rochester, Minn, USA, 1997.
[23]
D. P. van Kammen, W. B. van Kammen, J. L. Peters, et al., “CSF MHPG sleep and psychosis in schizophrenia,” Clinical Neuropharmacology, vol. 9, no. 4, pp. 575–577, 1986.
[24]
E. O. Johnson, T. Roth, and N. Breslau, “The association of insomnia with anxiety disorders and depression: exploration of the direction of risk,” Journal of Psychiatric Research, vol. 40, no. 8, pp. 700–708, 2006.
[25]
M. J. Peterson, M. E. Rumble, and R. M. Benca, “Insomnia and psychiatric disorders,” Psychiatric Annals, vol. 38, no. 9, pp. 597–605, 2008.
[26]
E. Collier, G. Skitt, and H. Cutts, “A study on the experience of insomnia in a psychiatric inpatient population,” Journal of Psychiatric and Mental Health Nursing, vol. 10, no. 6, pp. 697–704, 2003.
[27]
W. B. Mendelson, “Combining pharmacologic and nonpharmacologic therapies for insomnia,” Journal of Clinical Psychiatry, vol. 68, no. 5, pp. 19–23, 2007.
[28]
J. D. Hoehns and P. J. Perry, “Zolpidem: a nonbenzodiazepine hypnotic for treatment of insomnia,” Clinical Pharmacy, vol. 12, no. 11, pp. 814–828, 1993.
[29]
M. B. Scharf, T. Roth, G. W. Vogel, and J. K. Walsh, “A multicenter, placebo-controlled study evaluating Zolpidem in the treatment of chronic insomnia,” Journal of Clinical Psychiatry, vol. 55, no. 5, pp. 192–199, 1994.
[30]
S. H. Shaw, H. Curson, and J. P. Coquelin, “A double-blind, comparative study of zolpidem and placebo in the treatment of insomnia in elderly psychiatric in-patients,” Journal of International Medical Research, vol. 20, no. 2, pp. 150–161, 1992.
[31]
M. J. Sateia and P. D. Nowell, “Insomnia,” The Lancet, vol. 364, no. 9449, pp. 1959–1973, 2004.
[32]
W. V. McCall, “Pharmacologic treatment of insomnia,” in Sleep Medicine, T. L. Lee-Ching, M. J. Satia, and M. A. Carskadon, Eds., pp. 169–176, Hanley and Blfus, Philadelphia, Pa, USA, 2002.
[33]
J. Rathbone, L. Zhang, M. Zhang et al., “Chinese herbal medicine for schizophrenia: cochrane systematic review of randomised trials,” The British Journal of Psychiatry, vol. 190, pp. 379–384, 2007.
[34]
J. T. Shuval, N. Mizrachi, and E. Smetannikov, “Entering the well-guarded fortress: alternative practitioners in hospital settings,” Social Science and Medicine, vol. 55, no. 10, pp. 1745–1755, 2002.
[35]
J. Rathbone and J. Xia, “Acupuncture for schizophrenia,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD005475, 2005.
[36]
M. S. Lee, B. C. Shin, P. Ronan, and E. Ernst, “Acupuncture for schizophrenia: a systematic review and meta-analysis,” International Journal of Clinical Practice, vol. 63, no. 11, pp. 1622–1633, 2009.
[37]
H. MacPherson, K. Thomas, S. Walters, and M. Fitter, “The York acupuncture safety study: prospective survey of 34 000 treatments by traditional acupuncturists,” The British Medical Journal, vol. 323, no. 7311, pp. 486–487, 2001.
[38]
C. M. H. Goertz, R. Niemtzow, S. M. Burns, M. J. Fritts, C. C. Crawford, and W. B. Jonas, “Auricular acupuncture in the treatment of acute pain syndromes: a pilot study,” Military Medicine, vol. 171, no. 10, pp. 1010–1014, 2006.
[39]
R. C. Kessler, J. Soukup, R. B. Davis et al., “The use of complementary and alternative therapies to treat anxiety and depression in the United States,” The American Journal of Psychiatry, vol. 158, no. 2, pp. 289–294, 2001.
[40]
D. K. Cheuk, W. F. Yeung, K. F. Chung, and V. Wong, “Acupuncture for insomnia,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD005472, 2007.
[41]
W. F. Yeung, K. F. Chung, M. M. Poon et al., “Acupressure, reflexology, and auricular acupressure for insomnia: a systematic review of randomized controlled trials,” Sleep Medicine, vol. 13, no. 8, pp. 971–984, 2012.
[42]
M. D. Kutch, “Cost-effectiveness analysis of complementary and alternative medicine in treating mental health disorders,” Dissertation Abstracts International A, vol. 71, no. 11, p. 4102, 2011.
[43]
World Health Organisation, International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10), WHO, Geneva, Switzerland, 1992.
[44]
J. Zomer, R. Peled, A. H. E. Rubin, and P. Lavie, “Mini Sleep Questionnaire (MSQ) for screening large populations for EDS complaints,” in Sleep 1984, W. P. Koella, E. Ruther, and H. Schulz, Eds., pp. 467–469, Gustav Fischer, New York, NY, USA, 1985.
[45]
O. Tzischinsky, A. Cohen, E. Doveh et al., “Screening for sleep disordered breathing among applicants for a professional driver's license,” Journal of Occupational and Environmental Medicine, vol. 54, no. 10, pp. 1275–1280, 2012.
[46]
I. Haimov, N. Breznitz, and S. Shiloh, “Sleep in healthy elderly: sources of discrepancy between self-report and recorded sleep,” in Clinical and Neurophysiological Aspects of Sleep, V. M. Kumar and H. N. Mallick, Eds., pp. 145–148, Medimond, International Proceedings, 2006.
[47]
T. Shochat, O. Tzischinsky, A. Oksenberg, and R. Peled, “Validation of the Pittsburgh sleep quality index hebrew translation (PSQI-H) in a sleep clinic sample,” Israel Medical Association Journal, vol. 9, no. 12, pp. 853–856, 2007.
[48]
J. O. Brooks III, L. Friedman, D. L. Bliwise, and J. A. Yesavage, “Use of the wrist actigraph to study insomnia in older adults,” Sleep, vol. 16, no. 2, pp. 151–155, 1993.
[49]
C. Mccall and W. V. Mccall, “Comparison of actigraphy with polysomnography and sleep logs in depressed insomniacs,” Journal of Sleep Research, vol. 21, no. 1, pp. 122–127, 2012.
[50]
J. E. Overall and D. E. Gorham, “The brief psychiatric rating scale,” Psychological Reports, vol. 10, no. 3, pp. 799–812, 1962.
[51]
M. Sherwood, A. E. Thornton, and W. G. Honer, “A quantitative review of the profile and time course of symptom change in schizophrenia treated with clozapine,” Journal of Psychopharmacology, vol. 26, no. 9, pp. 1175–1184, 2012.
[52]
S. R. Kay, L. A. Opler, and J. P. Lindenmayer, “Reliability and validity of the positive and negative syndrome scale for schizophrenics,” Psychiatry Research, vol. 23, no. 1, pp. 99–110, 1988.
[53]
A. T. Beck and R. A. Steer, Beck Depression Inventory Manual, The Psychological Corporation, San Antonio, Tex, USA, 1987.
[54]
Y. J. Lee, S. J. Cho, I. H. Cho, J. H. Jang, and S. J. Kim, “The relationship between psychotic-like experiences and sleep disturbances in adolescents,” Sleep Medicine, vol. 13, no. 8, pp. 1021–1027, 2012.
[55]
A. T. Beck, R. A. Steer, and M. G. Garbin, “Psychometric properties of the beck depression inventory: twenty-five years of evaluation,” Clinical Psychology Review, vol. 8, no. 1, pp. 77–100, 1988.
[56]
M. J. Müller, H. Brening, C. Gensch, J. Klinga, B. Kienzle, and K. M. Müller, “The calgary depression rating scale for schizophrenia in a healthy control group: psychometric properties and reference values,” Journal of Affective Disorders, vol. 88, no. 1, pp. 69–74, 2005.
[57]
R. Schennach, M. Obermeier, F. Seemüller et al., “Evaluating depressive symptoms in schizophrenia: a psychometric comparison of the calgary depression scale for schizophrenia and the Hamilton depression rating scale,” Psychopathology, vol. 45, no. 5, pp. 276–285, 2012.
[58]
O. Schwartz-Stav, A. Apter, and G. Zalsman, “Depression, suicidal behavior and insight in adolescents with schizophrenia,” European Child and Adolescent Psychiatry, vol. 15, no. 6, pp. 352–359, 2006.
[59]
A. Okun, R. E. K. Stein, L. J. Bauman, and E. J. Silver, “Content validity of the psychiatric symptom index, CES-depression scale, and state-trait anxiety inventory from the perspective of DSM-IV,” Psychological Reports, vol. 79, no. 3, pp. 1059–1069, 1996.
[60]
C. D. Spielberger, R. L. Gorusch, and R. E. Lushene, Manual for the State-Trait Inventory (Self-Evaluation Questionnaire), Consulting Psychologists Press, Palo Alto, Calif, USA, 1970.
[61]
R. Meades and S. Ayers, “Anxiety measures validated in perinatal populations: a systematic review,” Journal of Affective Disorders, vol. 133, no. 1-2, pp. 1–15, 2011.
[62]
W. Maier, R. Buller, M. Philipp, and I. Heuser, “The Hamilton anxiety scale: reliability, validity and sensitivity to change in anxiety and depressive disorders,” Journal of Affective Disorders, vol. 14, no. 1, pp. 61–68, 1988.
[63]
M. Bellani, J. P. Hatch, M. A. Nicoletti et al., “Does anxiety increase impulsivity in patients with bipolar disorder or major depressive disorder?” Journal of Psychiatric Research, vol. 46, no. 5, pp. 616–621, 2012.
[64]
R. P. Snaith, M. Hamilton, S. Morley, A. Humayan, D. Hargreaves, and P. Trigwell, “A scale for the assessment of hedonic tone. The Snaith-Hamilton pleasure scale,” The British Journal of Psychiatry, vol. 167, no. 1, pp. 99–103, 1995.
[65]
J. Thomas, M. Al Ali, A. Al Hashmi, and A. Rodriguez, “Convergent validity and internal consistency of an Arabic Snaith Hamilton pleasure acale,” International Perspectives in Psychology: Research, Practice, Consultation, vol. 1, no. 1, pp. 46–51, 2012.
[66]
J. Endicott, J. Nee, W. Harrison, and R. Blumenthal, “Quality of life enjoyment and satisfaction questionnaire: a new measure,” Psychopharmacology Bulletin, vol. 29, no. 2, pp. 321–326, 1993.
[67]
A. Luquiens, M. Reynaud, B. Falissard, and H. J. Aubin, “Quality of life among alcohol-dependent patients: How satisfactory are the available instruments? A systematic review,” Drug and Alcohol Dependence, vol. 125, no. 3, pp. 192–201, 2012.
[68]
P. Deadman and M. Al-Khafaji, A Manual of Acupuncture, Journal of Chinese Medicine Publications, England, UK, 1998.
[69]
B. Bloch, S. Ravid, L. Vadas et al., “The acupuncture treatment of schizophrenia: a review with case studies,” Journal of Chinese Medicine, no. 93, pp. 57–63, 2010.
[70]
I. V. Zhdanova, R. J. Wurtman, M. M. Regan, J. A. Taylor, J. P. Shi, and O. U. Leclair, “Melatonin treatment for age-related insomnia,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 10, pp. 4727–4730, 2001.
[71]
L. Zhang and Z. Zhao, “Objective and subjective measures for sleep disorders,” Neuroscience Bulletin, vol. 23, no. 4, pp. 236–240, 2007.
[72]
I. Kobayashi, J. M. Boarts, and D. L. Delahanty, “Polysomnographically measured sleep abnormalities in PTSD: a meta-analytic review,” Psychophysiology, vol. 44, no. 4, pp. 660–669, 2007.
[73]
E. Klein, D. Koren, I. Arnon, and P. Lavie, “Sleep complaints are not corroborated by objective sleep measures in post-traumatic stress disorder: a 1-year prospective study in survivors of motor vehicle crashes,” Journal of Sleep Research, vol. 12, no. 1, pp. 35–41, 2003.
[74]
M. Matousek, K. Cervena, L. Zavesicka, and M. Brunovsky, “Subjective and objective evaluation of alertness and sleep quality in depressed patients: correlation between the patients' statements and polygraphic findings,” BMC Psychiatry, vol. 4, article 14, 2004.
[75]
M. Pompili, X. F. Amador, P. Girardi et al., “Suicide risk in schizophrenia: learning from the past to change the future,” Annals of General Psychiatry, vol. 6, article 10, 2007.
[76]
R. A. Emsley, P. P. Oosthuizen, A. F. Joubert, M. C. Roberts, and D. J. Stein, “Depressive and anxiety symptoms in patients with schizophrenia and schizophreniform disorder,” Journal of Clinical Psychiatry, vol. 60, no. 11, pp. 747–751, 1999.
[77]
R. J. Bragaa, M. V. Mendlowicza, R. P. Marrocosd, and I. L. Figueiraa, “Anxiety disorders in outpatients with schizophrenia: prevalence and impact on the subjective quality of life,” Journal of Psychiatric Research, vol. 39, no. 4, pp. 409–414, 2005.