Background. Elderly patients have unique age-related comorbidities that may lead to an increase in postoperative complications involving neurological, pulmonary, cardiac, and endocrine systems. There has been an increase in the number of elderly patients undergoing surgery as this portion of the population is increasing in numbers. Despite advances in perioperative anesthesia and analgesia along with improved delivery systems, monotherapy with opioids continues to be the mainstay for treatment of postop pain. Reliance on only opioids can oftentimes lead to inadequate pain control or increase in the incidence of adverse events. Multimodal analgesia incorporating regional anesthesia is a promising alternative that may reduce needs for high doses and dependence on opioids along with any potential associated adverse effects. Methods. The following databases were searched for relevant published trials: Cochrane Central Register of Controlled Trials and PubMed. Textbooks and meeting supplements were also utilized. The authors assessed trial quality and extracted data. Conclusions. Multimodal drug therapy and perioperative regional techniques can be very effective to perioperative pain management in the elderly. Regional anesthesia as part of multimodal perioperative treatment can often reduce postoperative neurological, pulmonary, cardiac, and endocrine complications. Regional anesthesia/analgesia has not been proven to improve long-term morbidity but does benefit immediate postoperative pain control. In addition, multimodal drug therapy utilizes a variety of nonopioid analgesic medications in order to minimize dosages and adverse effects from opioids while maximizing analgesic effect and benefit. 1. Introduction The complex and multifactorial processes of aging can encompass all human organ systems. Secondary to cumulative effect(s) of comorbid condition(s) and diminished physiologic reserve, perioperative stresses can interfere with physiologic homeostasis and lead to potential deleterious adverse effects (AE). With an increase in number of elderly patients undergoing surgery, it is important to determine optimal perioperative therapies to improve recovery while minimizing AE for older surgical patients. A contribution to development of perioperative complications for patients is improper/inadequate postoperative pain therapy. Inadequate postsurgical pain management can be associated with poor interventional outcomes with potential higher rate(s) of medical complications, decreased perioperative pain anesthesia/analgesia experience for patients, and patient
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