The subchronic effect of aqueous stem bark extract of Khaya senegalensis on some biochemical, haematological, and histopathological parameters of rats was investigated. The rats were divided into six groups of five rats per group. Groups I to VI were administered graded doses of 0, 400, 800, 1200, 1600, and 2000？mg/kg？bw, respectively. The result of study revealed that administration of the Khaya senegalensis for twenty-eight days at the experimental dose resulted in significant ( ) increase in urea, electrolytes (Na+, K+), and creatinine levels. The extract also significantly ( ) increased serum activity of ALT, AST, and ALP. The levels of protein, albumin, and bilirubin were significantly changed when compared to their control values, but they were not dose dependent. The hematological indices assayed in this study were not significantly affected at the experimental dose when compared to the control values. Histological studies of the liver showed cellular degeneration and necrosis and bile duct hyperplasia and fibrosis with lymphocytic infiltration of the hepatocyte, providing supportive evidence for discussing the biochemical findings, indicative of functional derangement. The histological architecture of the kidney and that of the heart were however preserved. The result of this study indicates that the aqueous stem bark extract of K. senegalensis may affect the cellular integrity of vital organs of the body. 1. Introduction The therapeutic value of medicinal plants has long been exploited for the management of various disease conditions in traditional practice. This practice has gained appreciable acceptance in health care delivery in developing and developed nations with the notion that they are relatively harmless, but research is beginning to show that some of them may be toxic. Khaya senegalensis (Desr.) A. Juss (Family: Meliaceae) is a tree that is widely distributed in the sub-Saharan savannah from Senegal to Sudan and Uganda. It is a round evergreen crown of dark shiny foliage, pinnate leaves, and characteristic round capsules that grows up to 40？m high [1]. The therapeutic value of Khaya senegalensis has been recognized in different systems of traditional medicine for the treatment of various conditions. The decoction of the stem bark extract is commonly used for treating jaundice, dermatoses, malaria, fever, mucous diarrhea, and venereal diseases as well as for hookworm infection and a taeniacide remedy [2, 3]. Khaya senegalensis extracts have been reported to exhibit anti-inflammatory effects [4] as well as anti-bacterial [5],
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