This paper is the first of its kind for development of rapid and ecofriendly method for synthesis of silver nanoparticles from aqueous solution of silver nitrate using the flavonoid “hesperidin” and optimization of the methodology. There is formation of stable spherical silver nanoparticles in the size range of 20–40？nm. Optimization of methodology in terms of concentration of reactants and pH of the reaction mixture reduced the reaction time for silver nanoparticle formation to 2？mins. Silver nanoparticles (AgNPs) were characterized by UV-Vis spectroscopy and transmission electron microscopy (TEM). UV-vis spectroscopy derived spectrum demonstrated a peak of 430？nm which corresponds to the plasmon absorbance of silver nanoparticles. Transmission electron microscopy revealed spherical shaped silver nanoparticles in the size range of 20–40？nm. 1. Introduction Nanoparticles have become a subject of intense interest among the research community. These interests have been aroused by the lacunae in knowledge associated with silver nanoparticles and also the gaining momentum with which researches are uncovering the obscurities in knowledge surrounding the nanosciences. There is a rapid growth in the field of nanotechnology over the past few years and it has successfully ventured into the field of clinical medicine. Silver nanoparticles (Ag NPs) have occupied a central position in terms of research among all other metal nanoparticles [1]. There are several methods of synthesis of silver nanoparticles most of which fall under categories like physical methods, chemical methods, and the ecofriendly biomimetic methods [2]. Biomimetic methods of synthesis are the result of a growing need to develop cheap and ecofriendly methods for synthesis [3]. Physical approach for synthesis has several methods like evaporation/condensation and laser ablation, while in the chemical approach, the metal ions in solution are reduced in conditions favoring the subsequent formation of small metal clusters or aggregates [4]. From the utility perspective, along with nanodimensions the particles should be dispersed without agglomeration as well [2]. The properties exhibited by the metallic nanoparticles are size- and shape-dependent [5–7]. Biomimetic synthesis of silver nanoparticles is cost effective and environmental friendly and is also safe for applications in therapeutics [8]. Biological methods have emerged as an alternative to the conventional methods for synthesis of silver nanoparticles. Nanoparticle synthesis by biological methods results in a safer and biocompatible end
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