Mangrove plants are specialised plants that grow in the tidal coasts of tropic and subtropic regions of the world. Their unique ecology and traditional medicinal uses of mangrove plants have attracted the attention of researchers over the years, and as a result, reports on biological activity of mangrove plants have increased significantly in recent years. This review has been set out to compile and appraise the results on antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants. While the Web of Knowledge, Google Scholar, and PubMed were the starting points to gather information, other pieces of relevant published literature were also adequately explored for this purpose. A total of 29 reports on 17 plant species have been found to report such activities. While 19 reports were on the biological activity of the crude extracts, 10 reports identified the active compound(s) of various chemical classes of natural products including terpenes, steroids, and flavonoids. This review finds that antinociceptive, anti-inflammatory, and antipyretic activity appears to be widespread in mangrove plants. 1. Introduction Mangrove forests are a special type of vegetation found in the coastal regions of the tropical and subtropical parts of the world. Global area that comprises mangrove forest is about 181000 square km. Majority of the mangrove forests is confined to the South East Asia and Australia, which accounts for 43% of the worldwide mangrove area (Table 1) [1, 2]. About 70 plant species of 27 genera have been reported from mangrove forests [2]. However, it should be noted that mangrove forests generally support the growth of non-mangrove plant species as well. For example, 334 plant species of 245 genera have been reported so far from the Sundarbans [3]. Flora of mangrove forests is unique from others in that their habitat extends along the border where the fresh and sea water merge. Therefore, unlike common terrestrial plants, they can withstand high salt concentration, can remain submerged in water, and maintain an efficient nutrient retention mechanism [1]. Table 1: Distribution of major mangrove forests around the world [ 2]. Mangrove forests are still quite unfamiliar to a vast population due to their limited distribution. However, the people inhabiting areas near mangrove forests heavily depend on these forests to meet their needs including their healthcare. During the early stage of human civilization, mangrove forests drew very little or no attention. This is to some extent because of the difficulty to access these areas. As the
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