The physiological age-related hearing loss is defined as presbycusis and it is characterized by reduced hearing sensitivity and problems in understanding spoken language especially in a noisy environment. In elderly the reduced speech recognition is generally caused by a reduction of the cochlear cells in the organ of Corti and degeneration of the central auditory pathways. In order to have a complete management strategy of central and peripheral presbycusis the diagnostic evaluation should include clinical ENT examination, standard audiological tests, and tests of central auditory function. Treatment should include not only the appropriate instruments for peripheral compensation but also auditory rehabilitative training and counseling to prevent social isolation and loss of autonomy. Other common hearing disorders in elderly are tinnitus and hyperacusis which are often undervalued. Tinnitus is characterized by the perception of a “phantom” sound due to abnormal auditory perception. Hyperacusis is defined as a reduced tolerance to ordinary environmental sounds. Furthermore auditory, visual, nociceptive, and proprioceptive systems may be involved together in a possible context of “sensorineural aging.” The aim of this review is to underline the presence of hearing disorders like tinnitus and hyperacusis which in many cases coexist with hearing loss in elderly. 1. Introduction Hearing loss affects approximately one-third of adults over 60 years [1]. Typical changes in presbycusis start with a hearing loss on high frequencies with a progression toward the lower frequencies and a deterioration of the hearing threshold [2]. Many factors contribute to presbycusis like morphological alterations in the stria vascularis, loss of hair cells in the cochlea, and degeneration of the central auditory pathway [3, 4], depending on a genetic basis, smoking, vascular changes, metabolic disorders, and environmental exposure to noise [5]. However, the originating signals that trigger these mechanisms remain unclear. Changes within the cochlea are responsible for age-related hearing loss typically linked with low speech understanding especially in presence of competing sound sources. The phenomenon of low speech understanding in elderly is related to modifications in central brain processes. Associations between hearing loss and blood lipids in older adults have been studied for many years. Currently the association is considered controversial [6]. Despite some limitations in data collection methods, interesting findings were proposed by Verschuur et al. about the
References
[1]
National Center for Health Statistics, Prevalence and Characteristics of Persons with Hearing Trouble, vol. 88, Department of Health Human Services, Public Health Service, 1994.
[2]
G. A. Gates and J. H. Mills, “Presbycusis,” The Lancet, vol. 366, no. 9491, pp. 1111–1120, 2005.
[3]
M. K. Pichora-Fuller and P. E. Souza, “Effects of aging on auditory processing of speech,” International Journal of Audiology, vol. 42, supplement 2, pp. S2–S11, 2003.
[4]
J. Mazelová, J. Popelar, and J. Syka, “Auditory function in presbycusis: peripheral vs. central changes,” Experimental Gerontology, vol. 38, no. 1-2, pp. 87–94, 2003.
[5]
E. Fransen, N. Lemkens, L. Van Laer, and G. Van Camp, “Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects,” Experimental Gerontology, vol. 38, no. 4, pp. 353–359, 2003.
[6]
A. N. Simpson, L. J. Matthews, and J. R. Dubno, “Lipid and C-reactive protein levels as risk factors for hearing loss in older adults,” Otolaryngology—Head and Neck Surgery, vol. 148, no. 4, pp. 664–670, 2013.
[7]
C. A. Verschuur, A. Dowell, H. E. Syddall et al., “Markers of inflammatory status are associated with hearing threshold in older people: findings from the hertfordshire ageing study,” Age and Ageing, vol. 41, no. 1, pp. 92–97, 2012.
[8]
G. A. Gates, M. L. Anderson, M. P. Feeney, S. M. McCurry, and E. B. Larson, “Central auditory dysfunction in older persons with memory impairment or alzheimer dementia,” Archives of Otolaryngology—Head and Neck Surgery, vol. 134, no. 7, pp. 771–777, 2008.
[9]
K. Demeester, A. Van Wieringen, J.-J. Hendrickx et al., “Prevalence of tinnitus and audiometric shape,” B-ENT, vol. 3, no. 7, pp. 37–49, 2007.
[10]
J. A. Vernon, “Pathophysiology of tinnitus: a special case-hyperacusis and a proposed treatment,” American Journal of Otolaryngology, vol. 8, pp. 201–202, 1987.
[11]
A. J. Klein, B. L. Armstrong, M. K. Greer, and F. R. Brown III, “Hyperacusis and otitis media in individuals with williams syndrome,” Journal of Speech and Hearing Disorders, vol. 55, no. 2, pp. 339–344, 1990.
[12]
G. Andersson, N. Lindvall, T. Hursti, and P. Carlbring, “Hypersensitivity to sound (hyperacusis): a prevalence study conducted via the internet and post,” International Journal of Audiology, vol. 41, no. 8, pp. 545–554, 2002.
[13]
R. Dauman and F. Bouscau-Faure, “Assessment and amelioration of hyperacusis in tinnitus patients,” Acta Oto-Laryngologica, vol. 125, no. 5, pp. 503–509, 2005.
[14]
D. M. Baguley, “Hyperacusis,” Journal of the Royal Society of Medicine, vol. 96, no. 12, pp. 582–585, 2003.
[15]
P. J. Jastreboff and M. M. Jastreboff, “Tinnitus retraining therapy (TRT) as a method for treatment of tinnitus and hyperacusis patients,” Journal of the American Academy of Audiology, vol. 11, no. 3, pp. 162–177, 2000.
[16]
M. Anari, A. Axelsson, A. Eliasson, and L. Magnusson, “Hypersensitivity to sound. Questionnaire data, audiometry and classification,” Scandinavian Audiology, vol. 28, no. 4, pp. 219–230, 1999.
[17]
K. N. Darrow, S. F. Maison, and M. C. Liberman, “Cochlear efferent feedback balances interaural sensitivity,” Nature Neuroscience, vol. 9, no. 12, pp. 1474–1476, 2006.
[18]
L. B. Minor, P. D. Cremer, J. P. Carey, C. C. Della Santina, S.-O. Streubel, and W. E. G. Noah, “Symptoms and signs in superior canal dehiscence syndrome,” Annals of the New York Academy of Sciences, vol. 942, pp. 259–273, 2001.
[19]
C. J. Mahoney, J. D. Rohrer, J. C. Goll, N. C. Fox, M. N. Rossor, and J. D. Warren, “Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 82, no. 11, pp. 1274–1278, 2011.
[20]
J. J. Eggermont and L. E. Roberts, “The neuroscience of tinnitus,” Trends in Neurosciences, vol. 27, no. 11, pp. 676–682, 2004.
[21]
B. Goldstein and A. Shulman, “Tinnitus-hyperacusis and the loudness discomfort level test-A preliminary report,” International Tinnitus Journal, vol. 2, pp. 83–89, 1996.
[22]
M. Nelting, N. K. Rienhoff, G. Hesse, et al., “Die Erfassung des subjektiven Leidens uner Hyperakusis mit einem Selbstbeurteilungsbogen zur Gerusch?berempfindlichkeit (GUF),” Laryngo-Rhino-Otologie, vol. 81, pp. 327–334, 2002.
[23]
C. Herráiz, G. De Los Santos, I. Diges, R. Díez, and J. M. Aparicio, “Assessment of Hyperacusis: the self-rating questionnaire on hypersensitivity to sound,” Acta Otorrinolaringologica Espanola, vol. 57, no. 7, pp. 303–306, 2006.
[24]
S. Khalfa, S. Dubal, E. Veuillet, F. Perez-Diaz, R. Jouvent, and L. Collet, “Psychometric normalization of a hyperacusis questionnaire,” ORL, vol. 64, no. 6, pp. 436–442, 2002.
[25]
P. J. Jastreboff and J. W. Hazell, Tinnitus Retraining Therapy: Implementing the Neurophysiological Model, Cambridge University Press, New York, NY, USA, 2007.
[26]
A. Schr?der, N. Vulink, and D. Denys, “Misophonia: diagnostic criteria for a new psychiatric disorder,” PLoS ONE, vol. 8, no. 1, Article ID e54706, 2013.
[27]
M. Edelstein, D. Brang, R. Rouw, et al., “Misophonia: physiological investigations and case descriptions,” Frontiers in Human Neuroscience, vol. 7, article 296, 2013.
[28]
B. C. J. Moore, “Psychoacoustics of normal and impaired hearing,” British Medical Bulletin, vol. 63, pp. 121–134, 2002.
[29]
Z. Mao, L. Zhao, L. Pu, et al., “How well can centenarians hear?” PLoS ONE, vol. 8, no. 6, Article ID e65565, 2013.
[30]
R. M. Sapolsky, “Neuroprotective gene therapy against acute neurological insults,” Nature Reviews Neuroscience, vol. 4, no. 1, pp. 61–69, 2003.
[31]
R. F. Uhlmann, E. B. Larson, T. S. Rees, T. D. Koepsell, and L. G. Duckert, “Relationship of hearing impairment to dementia and cognitive dysfunction in older adults,” Journal of the American Medical Association, vol. 261, no. 13, pp. 1916–1919, 1989.
[32]
E. Idrizbegovic, C. Hederstierna, M. Dahlquist, C. K. Nordstr?m, V. Jelic, and U. Rosenhall, “Central auditory function in early Alzheimer's disease and in mild cognitive impairment,” Age and Ageing, vol. 40, no. 2, pp. 249–254, 2011.
[33]
H. Wang, J. G. Turner, L. Ling, J. L. Parrish, L. F. Hughes, and D. M. Caspary, “Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus,” Neuroscience, vol. 160, no. 1, pp. 227–239, 2009.
[34]
L. F. Hughes, J. G. Turner, J. L. Parrish, and D. M. Caspary, “Processing of broadband stimuli across A1 layers in young and aged rats,” Hearing Research, vol. 264, no. 1-2, pp. 79–85, 2010.
[35]
O. Profant, Z. Balogová, M. Dezortová, et al., “Metabolic changes in the auditory cortex in presbycusis demonstrated by MR spectroscopy,” Experimental Gerontology, vol. 48, no. 8, pp. 795–800, 2013.
[36]
D. Clinkard, H. Amoodi, T. Kandasamy, et al., “Changes in the cochlear vasculature and vascular endothelial growth factor and its receptors in the aging c57 mouse cochlea,” ISRN Otolaryngol, vol. 2013, Article ID 430625, 6 pages, 2013.
[37]
J.-H. Hwang, C.-W. Li, C.-W. Wu, J.-H. Chen, and T.-C. Liu, “Aging effects on the activation of the auditory cortex during binaural speech listening in white noise: an fMRI study,” Audiology and Neurotology, vol. 12, no. 5, pp. 285–294, 2007.
[38]
A. Shulman, B. Goldstein, and A. M. Strashun, “Central nervous system neurodegeneration and tinnitus: a clinical experience Part I: diagnosis,” International Tinnitus Journal, vol. 13, no. 2, pp. 118–131, 2007.
[39]
A. Shulman, “A final common pathway for tinnitus—medial temporal lobe system,” The International Tinnitus Journal, vol. 1, pp. 115–126, 1995.
[40]
J. J. Song, D. De Ridder, N. Weisz, et al., “Hyperacusis-associated pathological resting-state brain oscillations in the tinnitus brain: a hyperresponsiveness network with paradoxically inactive auditory cortex,” Brain Structure and Function, 2013.
[41]
H. H. Kr?mer, C. Stenner, S. Seddigh, T. Bauermann, F. Birklein, and C. Maih?fner, “Illusion of pain: pre-existing knowledge determines brain activation of “imagined allodynia”,” Journal of Pain, vol. 9, no. 6, pp. 543–551, 2008.
[42]
O. L. M. Cruz, C. A. Kasse, M. Sanchez, F. Barbosa, and F. A. Barros, “Serotonin reuptake inhibitors in auditory processing disorders in elderly patients: preliminary results,” Laryngoscope, vol. 114, no. 9 I, pp. 1656–1659, 2004.
[43]
J.-H. Hwang, P.-H. Chou, C.-W. Wu, J.-H. Chen, and T.-C. Liu, “Brain activation in patients with idiopathic hyperacusis,” American Journal of Otolaryngology—Head and Neck Medicine and Surgery, vol. 30, no. 6, pp. 432–434, 2009.
[44]
M. J. M. De Klaver, M. A. Van Rijn, J. Marinus, W. Soede, J. A. P. M. De Laat, and J. J. Van Hilten, “Hyperacusis in patients with complex regional pain syndrome related dystonia,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 78, no. 12, pp. 1310–1313, 2007.
[45]
D. Hasson, T. Theorell, J. Bergquist, et al., “Acute stress induces hyperacusis in women with high levels of emotional exhaustion,” PLoS ONE, vol. 8, no. 1, Article ID e52945, 2013.
[46]
A. Parbery-Clark, E. Skoe, and N. Kraus, “Musical experience limits the degradative effects of background noise on the neural processing of sound,” Journal of Neuroscience, vol. 29, no. 45, pp. 14100–14107, 2009.
[47]
V. Bernabei, V. Morini, F. Moretti et al., “Vision and hearing impairments are associated with depressive-anxiety syndrome in Italian elderly,” Aging and Mental Health, vol. 15, no. 4, pp. 467–474, 2011.