The present study was carried out to investigate independent relationship between daily physical activity, microalbuminuria, and kidney function. The demographic characteristics and laboratory parameters were recorded for all patients. The determination of daily activities was carried out by Nottingham Extended Activities of Daily Living Scale (NEADLS) which was performed for each patient in an interview. Totally 139 patients were enrolled. In the whole group NEADLS score was correlated with age (rho: ？0.759, ), clinical systolic blood pressure (rho: ？0.212, : 0.018), blood urea nitrogen (rho: ？0.516, ), creatinine (rho: ？0.501, ), uric acid (rho: ？0.308, ), albumin (rho: 0.382, ), total cholesterol (rho: ？0.194, : 0.022), LDL-cholesterol (rho: ？0.230, : 0.008), hemoglobin (rho: 0.256, : 0.002), creatinine clearance (rho: 0.565, ), 24-hour urinary protein excretion (rho: ？0.324, ), and 24-hour urinary albumin excretion (UAE) (rho: ？0.483, ). The multivariate linear regression of independent factors corelated with logarithmically converted NEADLS score (as a dependent variable) has shown that age ( ), presence of coronary artery disease ( : 0.011), hemoglobin ( : 0.020), 24-hour creatinine clearance ( : 0.004), and 24-hour urinary albumin excretion ( ) were independently corelated with NEADLS score. In conclusion, both UAE and kidney function were independently associated with daily physical activity. 1. Introduction Patients with chronic kidney disease (CKD) often have decreased physical fitness and activity [1]. The main causes are muscle atrophy [2], myopathy [3], inactivity [4], malnutrition [5], and lower albumin levels [6]. Besides, anemia, inflammation, and uremic acidosis also play a role [7]. It was well demonstrated that increased urinary protein and albumin excretion are well-known risk factors for cardiovascular end-organ damage [8, 9]. Emerging data suggest that greater physical activity may be associated with less albuminuria and physical activity could protect against albuminuria [10, 11]. However, the relationship between physical activity and albuminuria is not uniform. For example, in diabetic patients, physical activity is associated with lower albumin excretion, and physical activity has led to regression of albuminuria in interventional studies [12, 13]. However, in nondiabetics these associations were not observed [14, 15]. The relationship between physical activity and albumin/protein excretion become more complex by the phenomenon of postexercise proteinuria. Transient proteinuria, including albuminuria, is common after intense
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