A total of 8898 Chinese children (4580 boys and 4318 girls) aged 7–13 years in 6 cities of east China were recruited. Data on height, weight, waist circumference, blood pressure, serum lipid profiles, glucose, and insulin were collected. The overall prevalence of hypertension was 11.1%. Overweight and obese children had a higher risk of developing hypertension than their counterparts (29.1%, 17.4%, and 7.8%, resp.) ( ). The means levels of triglycerides, glucose, insulin, and HOMA-IR (1.0？mmol/L, 4.5？mmol/L, 8.4？mU/mL and 1.7, resp.) among hypertensive children were all significantly higher than their normotensive counterparts (0.8？mmol/L, 4.5？mmol/L, 5.9？mU/mL, and 1.2, resp.) ( ). Compared with the healthy children, the risk (odds ratio, OR) of having hypertension among children with high triglycerides, hyperglycemia, and metabolic syndrome was 1.4 (95% confidence interval (CI): 1.0–2.0, ), 1.5 (95% CI: 0.9–2.5, ), and 2.8 (95%CI: 1.5–5.4, ), respectively, after controlling for age, gender, BMI, income level, parents' education level and puberty. In conclusion, overweight and obese children have higher risk of having hypertension and children with dyslipidemia, hyperglycemia, and metabolic syndrome and higher HOMA-IR have higher risk of developing hypertension. 1. Introduction Hypertension is a major public health problem worldwide. In China, the prevalence of hypertension was 17.7% in 2002 and it was estimated that the number of adults with hypertension was 174 million and 220 thousands died from hypertension annually, respectively. About 2.54 million life years might be lost potentially due to hypertension. Every hypertensive patient led about 11.4 years life lost on average. Moreover, the direct economic burden reached 31.89 billion RMB [1]. It is well known that hypertension is one of the major risk factors for coronary artery disease and cerebrovascular disease [2, 3]. Development of adult hypertension and the adverse effects of elevated blood pressure on vascular structure and function may start very early in life [4–8]. Obesity is well known as one predictor of hypertension [9]. Some studies also showed the relationship between hypertension and cholesterol, glucose, insulin, and insulin resistance [10, 11]. However, these relationships appear to vary among ethnic groups [12]. The data on the relationship between hypertension and lipid profiles, glucose, insulin, and insulin resistance among Chinese children were limited. Therefore, the purpose of the present study was to explore the association of hypertension with obesity, metabolic
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