The main indications for interhospital neonatal transports are radiographic studies (e.g., magnet resonance imaging) and surgical interventions. Specialized neonatal transport teams need to be skilled in patient care, communication, and equipment management and extensively trained in resuscitation, stabilization, and transport of critically ill infants. However, there is increasing evidence that clinical assessment of heart rate, color, or chest wall movements is imprecise and can be misleading even in experienced hands. The aim of the paper was to review the current evidence on clinical monitoring equipment during interhospital neonatal transport. 1. Introduction The main indications for interhospital neonatal transports are radiographic studies (e.g., magnet resonance imaging) and surgical interventions. Specialized neonatal transport teams need to be skilled in patient care, communication, and equipment management and extensively trained in resuscitation, stabilization, and transport of critically ill infants [1]. Clinical monitoring equipment routinely used in the neonatal intensive care unit (NICU) may not function optimally under transport conditions [2]. Both the critically ill neonate and the neonatal transport team are exposed to mechanical stressors (e.g., shock, vibration, and noise) making clinical assessment during transport almost impossible [1, 3–9]. However, most of the equipment routinely used in the NICU to support clinical management decisions has not been evaluated in the transport environment. The aim of the paper was to review the current evidence on clinical monitoring equipment during interhospital neonatal transport. 2. Search Strategies The aim of this paper is to review the available literature about monitoring during interhospital neonatal transport. We reviewed books, resuscitation manuals, and articles from 1950 to the present with the search terms “infant,” “newborn,” “neonatal transport,” “pulse oximetry,” “heart rate,” “respiratory function tests,” “carbon dioxide,” “temperature,” “blood pressure monitoring” and “transport scores.” The full search strategy for PubMed is detailed in the Appendix. 3. Pulse Oximetry and Heart Rate Neonatal transports carried out overnight make the assessment of an infant’s color challenging. In addition, incubators are covered to decrease environmental impact, which blocks light inside the incubator making color assessment challenging. Furthermore, judging an infants color to determine oxygen saturation is imprecise [10]. During neonatal transport, vibration can cause intermittent failure
References
[1]
M. O’Reilly and G. M. Schm?lzer, “Monitoring during Neonatal transport,” Emergency Medicine, vol. 1, 2012.
[2]
M. H. Stroud, P. Prodhan, M. Moss, R. Fiser, S. Schexnayder, and K. Anand, “Enhanced monitoring improves pediatric transport outcomes: a randomized controlled trial,” Pediatrics, vol. 127, no. 1, pp. 42–48, 2011.
[3]
A. Meberg, “Neonatal transports—risks and opportunities,” Open Journal of Pediatrics, vol. 1, pp. 45–50, 2011.
[4]
S. T. Kempley, N. Ratnavel, and T. Fellows, “Vehicles and equipment for land-based neonatal transport,” Early Human Development, vol. 85, no. 8, pp. 491–495, 2009.
[5]
L. Jackson and C. H. Skeoch, “Setting up a neonatal transport service: air transport,” Early Human Development, vol. 85, no. 8, pp. 477–481, 2009.
[6]
L. Short, R. B. Hecker, R. E. Middaugh, and E. J. Menk, “A comparison of pulse oximeters during helicopter flight,” Journal of Emergency Medicine, vol. 7, no. 6, pp. 639–643, 1989.
[7]
S. E. Sittig, J. C. Nesbitt, D. A. Krageschmidt, S. C. Sobczak, and R. V. Johnson, “Noise levels in a neonatal transport incubator in medically configured aircraft,” International Journal of Pediatric Otorhinolaryngology, vol. 75, no. 1, pp. 74–76, 2011.
[8]
R. C. Hunt, D. M. Bryan, V. S. Brinkley, T. W. Whitley, and N. H. Benson, “Inability to assess breath sounds during air medical transport by helicopter,” Journal of the American Medical Association, vol. 265, no. 15, pp. 1982–1984, 1991.
[9]
J. C. Bouchut, E. van Lancker, V. Chritin, and P. Y. Gueugniaud, “Physical stressors during neonatal transport: helicopter compared with ground ambulance,” Air Medical Journal, vol. 30, no. 3, pp. 134–139, 2011.
[10]
C. P. F. O'Donnell, C. O. F. Kamlin, P. G. Davis, et al., “Clinical assessment of infant colour at delivery,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 92, pp. F465–F467, 2007.
[11]
J. A. Langton and C. D. Hanning, “Effect of motion artefact on pulse oximeters: evaluation of four instruments and finger probes,” British Journal of Anaesthesia, vol. 65, no. 4, pp. 564–570, 1990.
[12]
R. Sahni, A. Gupta, K. Ohira-Kist, and T. S. Rosen, “Motion resistant pulse oximetry in neonates,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 88, no. 6, pp. F505–F508, 2003.
[13]
C. H. Yam, J. A. Dawson, G. M. Schm?lzer, et al., “Heart rate changes during resuscitation of newly born infants,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 96, pp. F102–F107, 2011.
[14]
J. Kattwinkel, J. M. Perlman, K. Aziz et al., “Part 15: neonatal resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care,” Circulation, vol. 122, no. 3, pp. S909–S919, 2010.
[15]
L. J. Bj?rklund, J. Ingimarsson, T. Curstedt et al., “Manual ventilation with a few large breaths at birth compromises the therapeutic effect of subsequent surfactant replacement in immature lambs,” Pediatric Research, vol. 42, no. 3, pp. 348–355, 1997.
[16]
C. O. F. Kamlin, C. P. F. O'Donnell, N. J. Everest, P. G. Davis, and C. J. Morley, “Accuracy of clinical assessment of infant heart rate in the delivery room,” Resuscitation, vol. 71, no. 3, pp. 319–321, 2006.
[17]
C. O. F. Kamlin, J. A. Dawson, C. P. F. O'Donnell et al., “Accuracy of pulse oximetry measurement of heart rate of newborn infants in the delivery room,” The Journal of Pediatrics, vol. 152, no. 6, pp. 756–760, 2008.
[18]
W. P. de Boode, “Clinical monitoring of systemic hemodynamics in critically ill newborns,” Early Human Development, vol. 86, no. 3, pp. 137–141, 2010.
[19]
S. Soleymani, M. Borzage, and I. Seri, “Hemodynamic monitoring in neonates: advances and challenges,” Journal of Perinatology, vol. 30, no. 1, pp. S38–S45, 2010.
[20]
S. Noori, A. Wlodaver, V. Gottipati, et al., “Transitional changes in cardiac and cerebral hemodynamics in term neonates at birth,” The Journal of Pediatrics, vol. 160, no. 6, pp. 943–948, 2012.
[21]
N. H. Hillman, S. G. Kallapur, J. J. Pillow et al., “Airway injury from initiating ventilation in preterm sheep,” Pediatric Research, vol. 67, no. 1, pp. 60–65, 2010.
[22]
D. A. Poulton, G. M. Schm?lzer, C. J. Morley, and P. G. Davis, “Assessment of chest rise during mask ventilation of preterm infants in the delivery room,” Resuscitation, vol. 82, no. 2, pp. 175–179, 2011.
[23]
G. M. Schm?lzer, C. O. F. Kamlin, C. P. F. O'Donnell, J. A. Dawson, C. J. Morley, and P. G. Davis, “Assessment of tidal volume and gas leak during mask ventilation of preterm infants in the delivery room,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 95, pp. F393–F397, 2010.
[24]
G. M. Schm?lzer, C. O. F. Kamlin, J. A. Dawson, et al., “Respiratory monitoring of neonatal resuscitation,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 95, pp. F295–F303, 2010.
[25]
G. M. Schm?lzer and C. C. Roehr, “Use of respiratory function monitors during simulated neonatal resuscitation,” Klinische P?diatrie, vol. 223, pp. 261–266, 2011.
[26]
C. Klingenberg, K. I. Wheeler, P. G. Davis, et al., “A practical guide to neonatal volume guarantee ventilation,” Journal of Perinatology, vol. 31, pp. 575–585, 2011.
[27]
G. M. Schm?lzer, C. J. Morley, C. Wong, et al., “Respiratory function monitor guidance of mask ventilation in the delivery room: a feasibility study,” The Journal of Pediatrics, vol. 160, pp. 377.e2–381.e2, 2012.
[28]
G. M. Schm?lzer, C. J. Morley, and P. G. Davis, “Respiratory function monitoring to reduce mortality and morbidity in newborn infants receiving resuscitation,” Cochrane Database of Systematic Reviews, vol. 9, Article ID CD008437, 2010.
[29]
G. M. Schm?lzer, A. B. te Pas, P. G. Davis, et al., “Reducing lung injury during neonatal resuscitation of preterm infants,” The Journal of Pediatrics, vol. 153, pp. 741–745, 2008.
[30]
G. R. Polglase, N. H. Hillman, J. J. Pillow et al., “Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs,” Pediatric Research, vol. 64, no. 5, pp. 517–522, 2008.
[31]
D. G. Tingay, M. J. Stewart, and C. J. Morley, “Monitoring of end tidal carbon dioxide and transcutaneous carbon dioxide during neonatal transport,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 90, no. 6, pp. F523–F526, 2005.
[32]
S. L. Barnes, R. Branson, L. A. Gallo, G. Beck, and J. A. Johannigman, “En-route care in the air: snapshot of mechanical ventilation at 37,000 feet,” The Journal of Trauma, vol. 64, no. 2, pp. S129–S134, 2008.
[33]
M. S. Bhende, V. A. Karr, D. C. Wiltsie, and R. A. Orr, “Evaluation of a portable infrared end-tidal carbon dioxide monitor during pediatric interhospital transport,” Pediatrics, vol. 95, no. 6, pp. 875–878, 1995.
[34]
A. B. te Pas, M. Siew, M. J. Wallace et al., “Effect of sustained inflation length on establishing functional residual capacity at birth in ventilated premature rabbits,” Pediatric Research, vol. 66, no. 3, pp. 295–300, 2009.
[35]
M. Tracy, L. Downe, and J. Holberton, “How safe is intermittent positive pressure ventilation in preterm babies ventilated from delivery to newborn intensive care unit?” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 89, no. 1, pp. F84–F87, 2004.
[36]
O. Dammann, E. N. Allred, L. J. van Marter, C. E. L. Dammann, and A. Leviton, “Bronchopulmonary dysplasia is not associated with ultrasound-defined cerebral white matter damage in preterm newborns,” Pediatric Research, vol. 55, no. 2, pp. 319–325, 2004.
[37]
C. D. Lilley, M. Stewart, and C. J. Morley, “Respiratory function monitoring during neonatal emergency transport,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 90, no. 1, pp. F82–F83, 2005.
[38]
C. P. F. O'Donnell, C. O. F. Kamlin, P. G. Davis, and C. J. Morley, “Neonatal resuscitation 1: a model to measure inspired and expired tidal volumes and assess leakage at the face mask,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 90, no. 5, pp. F388–F391, 2005.
[39]
G. M. Schm?lzer, D. A. Poulton, J. A. Dawson, C. O. F. Kamlin, C. J. Morley, and P. G. Davis, “Assessment of flow waves and colorimetric CO2 detector for endotracheal tube placement during neonatal resuscitation,” Resuscitation, vol. 82, no. 3, pp. 307–312, 2011.
[40]
G. M. Schm?lzer, S. B. Hooper, K. J. Crossley, B. J. Allison, C. J. Morley, and P. G. Davis, “Assessment of gas flow waves for endotracheal tube placement in an ovine model of neonatal resuscitation,” Resuscitation, vol. 81, no. 6, pp. 737–741, 2010.
[41]
G. Schm?lzer, R. Bhatia, P. G. Davis, and D. Tingay, “A comparison of different bedside techniques to determine endotracheal tube position in a neonatal piglet model,” Pediatric Pulmonology, vol. 48, no. 2, pp. 138–145, 2013.
[42]
G. M. Schm?lzer, J. A. Dawson, C. O. F. Kamlin, et al., “Airway obstruction and gas leak during mask ventilation of preterm infants in the delivery room,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 96, pp. F254–F257, 2011.
[43]
A. B. te Pas, C. Wong, C. O. F. Kamlin, J. A. Dawson, C. J. Morley, and P. G. Davis, “Breathing patterns in preterm and term infants immediately after birth,” Pediatric Research, vol. 65, no. 3, pp. 352–356, 2009.
[44]
A. B. te Pas, P. G. Davis, C. O. F. Kamlin, J. Dawson, C. P. F. O'Donnell, and C. J. Morley, “Spontaneous breathing patterns of very preterm infants treated with continuous positive airway pressure at birth,” Pediatric Research, vol. 64, no. 3, pp. 281–285, 2008.
[45]
A. B. te Pas, C. O. F. Kamlin, J. A. Dawson et al., “Ventilation and spontaneous breathing at birth of infants with congenital diaphragmatic hernia,” The Journal of Pediatrics, vol. 154, no. 3, pp. 369–373, 2009.
[46]
N. N. Finer, W. Rich, C. Wang, and T. Leone, “Airway obstruction during mask ventilation of very low birth weight infants during neonatal resuscitation,” Pediatrics, vol. 123, no. 3, pp. 865–869, 2009.
[47]
K. I. Wheeler, P. G. Davis, C. O. F. Kamlin, and C. J. Morley, “Assist control volume guarantee ventilation during surfactant administration,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 94, no. 5, pp. F336–F338, 2009.
[48]
G. M. Schm?lzer, C. O. F. Kamlin, J. A. Dawson, et al., “Tidal volume delivery during surfactant administration in the delivery room,” Intensive Care Medicine, vol. 37, no. 11, pp. 1833–1839, 2011.
[49]
A. B. te Pas, P. G. Davis, S. B. Hooper, and C. J. Morley, “From liquid to air: breathing after birth,” The Journal of Pediatrics, vol. 152, no. 5, pp. 607–611, 2008.
[50]
B. Lachmann, G. Grossmann, R. Nilsson, and B. Robertson, “Lung mechanics during spontaneous ventilation in premature and fullterm rabbit neonates,” Respiration Physiology, vol. 38, no. 3, pp. 283–302, 1979.
[51]
G. Lista, F. Castoldi, P. Fontana et al., “Lung inflammation in preterm infants with respiratory distress syndrome: effects of ventilation with different tidal volumes,” Pediatric Pulmonology, vol. 41, no. 4, pp. 357–363, 2006.
[52]
N. H. Hillman, T. J. M. Moss, S. G. Kallapur et al., “Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep,” American Journal of Respiratory and Critical Care Medicine, vol. 176, no. 6, pp. 575–581, 2007.
[53]
D. Dreyfuss and G. Saumon, “Barotrauma is volutrauma, but which volume is the one responsible?” Intensive Care Medicine, vol. 18, no. 3, pp. 139–141, 1992.
[54]
D. Dreyfuss and G. Saumon, “Role of tidal volume, FRC, and end-inspiratory volume in the development of pulmonary edema following mechanical ventilation,” American Review of Respiratory Disease, vol. 148, no. 5, pp. 1194–1203, 1993.
[55]
D. Dreyfuss, G. Basset, P. Soler, and G. Saumon, “Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats,” American Review of Respiratory Disease, vol. 132, no. 4, pp. 880–884, 1985.
[56]
M. South and C. J. Morley, “Monitoring spontaneous respiration in the ventilated neonate,” Archives of Disease in Childhood, vol. 61, pp. 291–294, 1986.
[57]
V. K. Bhutani, “Clinical applications of pulmonary function and graphics,” Seminars in Neonatology, vol. 7, no. 5, pp. 391–399, 2002.
[58]
S. Hosono, I. Inami, H. Fujita, M. Minato, S. Takahashi, and H. Mugishima, “A role of end-tidal CO2 monitoring for assessment of tracheal intubations in very low birth weight infants during neonatal resuscitation at birth,” Journal of Perinatal Medicine, vol. 37, no. 1, pp. 79–84, 2009.
[59]
C. O. F. Kamlin, C. P. F. O'Donnell, P. G. Davis, and C. J. Morley, “Colorimetric end-tidal carbon dioxide detectors in the delivery room: strengths and limitations. A case report,” The Journal of Pediatrics, vol. 147, no. 4, pp. 547–548, 2005.
[60]
L. L. D. Aliwalas, L. Noble, K. Nesbitt, S. Fallah, V. Shah, and P. S. Shah, “Agreement of carbon dioxide levels measured by arterial, transcutaneous and end tidal methods in preterm infants ≤28 weeks gestation,” Journal of Perinatology, vol. 25, no. 1, pp. 26–29, 2005.
[61]
A. Kugelman, D. Zeiger-Aginsky, D. Bader, I. Shoris, and A. Riskin, “A novel method of distal end-tidal CO2 capnography in intubated infants: comparison with Arterial CO2 and with proximal mainstream end-tidal CO2,” Pediatrics, vol. 122, no. 6, pp. e1219–e1224, 2008.
[62]
J. D. Tobias, “Transcutaneous carbon dioxide monitoring in infants and children,” Paediatric Anaesthesia, vol. 19, no. 5, pp. 434–444, 2009.
[63]
E. J. Molloy, “Are carbon dioxide detectors useful in neonates?” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 91, pp. F295–F298, 2006.
[64]
M. Vento, P. Y. Cheung, and M. Aguar, “The first golden minutes of the extremely-low-gestational-age neonate: a gentle approach,” Neonatology, vol. 95, no. 4, pp. 286–298, 2009.
[65]
E. D. Bowman and R. N. D. Roy, “Control of temperature during newborn transport: an old problem with new difficulties,” Journal of Paediatrics and Child Health, vol. 33, no. 5, pp. 398–401, 1997.
[66]
E. D. Johnston, J. C. Becher, A. P. Mitchell, and B. J. Stenson, “Provision of servo-controlled cooling during neonatal transport,” Archives of Disease in Childhood—Fetal and Neonatal Edition, 2011.
[67]
S. E. Jacobs, C. J. Morley, T. E. Inder et al., “Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial,” Archives of Pediatrics and Adolescent Medicine, vol. 165, no. 8, pp. 692–700, 2011.
[68]
F. Khurshid, K.-S. Lee, P. J. McNamara, et al., “Lessons learned during implementation of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy in a regional transport program in Ontario,” Paediatrics & Child Health, vol. 16, pp. 153–156, 2011.
[69]
K. Fairchild, D. Sokora, J. Scott, and S. Zanelli, “Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU,” Journal of Perinatology, vol. 30, no. 5, pp. 324–329, 2010.
[70]
G. S. Kendall, A. Kapetanakis, N. Ratnavel, D. Azzopardi, and N. J. Robertson, “Passive cooling for initiation of therapeutic hypothermia in neonatal encephalopathy,” Archives of Disease in Childhood—Fetal and Neonatal Edition, vol. 95, no. 6, pp. F408–F412, 2010.
[71]
S. K. Lee, J. A. Zupancic, J. Sale, et al., “Cost-effectiveness and choice of infant transport systems,” Medical Care, vol. 40, pp. 705–716, 2002.
[72]
M. C. Hermansen, S. Hasan, J. Hoppin, and M. D. Cunningham, “A validation of a scoring system to evaluate the condition of transported very-low-birthweight neonates,” American Journal of Perinatology, vol. 5, no. 1, pp. 74–78, 1988.
[73]
A. Ferrara and Y. Atakent, “Neonatal stabilization score. A quantitative method of auditing medical care in transported newborns weighing less than 1,000 g at birth,” Medical Care, vol. 24, no. 2, pp. 179–187, 1986.
[74]
S. K. Lee, J. A. F. Zupancic, M. Pendray et al., “Transport risk index of physiologic stability: a practical system for assessing infant transport care,” The Journal of Pediatrics, vol. 139, no. 2, pp. 220–226, 2001.
[75]
S. J. Broughton, A. Berry, S. Jacobe, P. Cheeseman, W. O. Tarnow-Mordi, and A. Greenough, “The mortality index for neonatal transportation score: a new mortality prediction model for retrieved neonates,” Pediatrics, vol. 114, no. 4, pp. e424–e428, 2004.
[76]
D. K. Richardson, J. D. Corcoran, G. J. Escobar, and S. K. Lee, “SNAP-II and SNAPPE-II: simplified newborn illness severity and mortality risk scores,” The Journal of Pediatrics, vol. 138, no. 1, pp. 92–100, 2001.
[77]
P. Lucas da Silva, V. Euzébio de Aguiar, and M. Reis, “Assessing outcome in interhospital infant transport: the transport risk index of physiologic stability score at admission,” American Journal of Perinatology, vol. 29, no. 7, pp. 509–514, 2012.