Chronic kidney disease related mineral and bone disease (CKD-MBD) is a worldwide challenge in hemodialysis patients. In china, the number of dialysis patients is growing but few data are available about their bone disorders. In the current study, we aimed to evaluate the effect of clinical factors on the serum phosphorus clearance in the 80 maintenance hemodialysis (MHD) patients. Six clinical factors were identified for their association with the serum phosphorus clearance using the analysis of Spearman’s single linear correlation, including predialysis serum phosphate level, CRR, membrane surface area of the dialyzer, effective blood flow rate, the blood chamber volume, and hematocrit. In an overall multivariate analysis, pre-P, CRR, membrane SA, and Qb were identified as independent risk factors associated with the serum phosphorus clearance. In conclusion, HD could effectively clear serum phosphorus. The analysis of CRR might help to estimate serum phosphorus reduction ratio. 1. Introduction In recent years, with the continuous improvement of the hemodialysis (HD) treatment and water quality, end-stage renal disease (ESRD) patients have led a gradually extended life, and their nutritional status has been improved. But at the same time, the calcium and phosphorus metabolism disorders and renal osteodystrophy are gradually becoming one of the long-term complications that affect the patient’s quality of life and survival time, wherein hyperphosphatemia is a common complication of chronic kidney disease and is also one of the risk factors for death in dialysis patients [1]. Studies have shown that increased serum phosphorus and calcium-phosphorus product is one of independent risk factors for cardiovascular complications in patients with ESRD [2]. The risk of coronary artery calcification caused by each additional 1？mg/dL of phosphorus is equivalent to an additional 2.5 years for HD [3]. Mason and Shepler [4]？ ？have reported that phosphorus levels of dialysis patients also have a direct relationship with mortality in patients undergoing maintenance HD. At present, few reports have been made about multivariate analysis of serum phosphorus clearance in single HD treatment. Therefore, we conducted this clinical observation, to further explore the factors related to serum phosphorus clearance. 2. Materials and Methods 2.1. Clinical Data As study subjects, we enrolled those patients who were treated in blood purification center of the Fourth Hospital of Hebei Medical University between June 2010 and February 2012. Dialysis patients were considered eligible
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