Background. Lymphoma of the urinary bladder (LUB) is rare. Aims. To review the literature on LUB. Methods. Various internet databases were used. Results. LUB can be either primary or secondary. The tumour has female predominance; most cases occur in middle-age women. Secondary LUB occurs in 10% to 25% of leukemias/lymphomas and in advanced-stage systemic lymphoma. Less than 100 cases have been reported. MALT typically affects adults older than 60 years; 75% are female. Diffuse large B-cell lymphoma is also common and may arise from transformation of MALT. LUB presents with haematuria, dysuria, urinary frequency, nocturia, and abdominal or back pain. Macroscopic examination of LUBs show large discrete tumours centred in the dome or lateral walls of the bladder. Positive staining of LUB varies by the subtype of lymphoma; B-cell lymphomas are CD20 positive. MALT lymphoma is positively stained for CD20, CD19, and FMC7 and negatively stained for CD5, CD10, and CD11c. LUB stains negatively with Pan-keratin, vimentin, CK20, and CK7. MALT lymphoma exhibits t(11; 18)(q21: 21). Radiotherapy is an effective treatment for the MALT type of LUB with no recurrence. Conclusions. LUB is diagnosed by its characteristic morphology and immunohistochemical characteristics. Radiotherapy is a useful treatment. 1. Introduction Lymphoma of the urinary bladder is an uncommon lesion; and its diagnostic features may not be well known by the unaccustomed practitioner. The ensuing document contains a review of the literature on lymphoma of the urinary bladder. 2. Methods The key words used for the search were Lymphoma of bladder; lymphoma of urinary bladder; vesical lymphoma. Documentations from 46 sources were found which had discussed various aspects relevant to lymphoma of the urinary bladder and information from these 46 sources were used to write the literature review. 3. Literature Review 3.1. Overview Definition. Lymphoma of the urinary bladder can be either (a) primary lymphoma of the urinary bladder and this is a rare lymphoma originating in the urinary bladder with no known lymphoma elsewhere or (b) secondary lymphoma of the urinary bladder and this is much more common, and this secondary lymphoma is associated with a primary lymphoma originating in an extra vesical site [1]. Epidemiology. Lymphomas of the urinary bladder have a female predominance, and most cases of lymphoma of the urinary bladder occur in middle-age women [1]. Secondary involvement of the urinary bladder occurs in 10% to 25% of leukemias/lymphomas and they occur in advanced-stage systemic lymphoma [1].
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