全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
PLOS ONE  2014 

Genetic Variability of Plasmodium malariae dihydropteroate synthase (dhps) in Four Asian Countries

DOI: 10.1371/journal.pone.0093942

Full-Text   Cite this paper   Add to My Lib

Abstract:

The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.

References

[1]  Imwong M, Pukrittakayamee S, Looareesuwan S, Pasvol G, Poirreiz J, et al. (2001) Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates. Antimicrob Agents Chemother 45: 3122–3127. doi: 10.1128/aac.45.11.3122-3127.2001
[2]  Imwong M, Pukrittayakamee S, Renia L, Letourneur F, Charlieu JP, et al. (2003) Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure. Antimicrob Agents Chemother 47: 1514–1521. doi: 10.1128/aac.47.5.1514-1521.2003
[3]  Plowe CV, Cortese JF, Djimde A, Nwanyanwu OC, Watkins WM, et al. (1997) Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J Infect Dis 176: 1590–1596. doi: 10.1086/514159
[4]  Zolg JW, Plitt JR, Chen GX, Palmer S (1989) Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol Biochem Parasitol 36: 253–262. doi: 10.1016/0166-6851(89)90173-4
[5]  Khim N, Kim S, Bouchier C, Tichit M, Ariey F, et al. (2012) Reduced impact of pyrimethamine drug pressure on Plasmodium malariae dihydrofolate reductase gene. Antimicrob Agents Chemother 56: 863–868. doi: 10.1128/aac.05284-11
[6]  Tanomsing N, Imwong M, Pukrittayakamee S, Chotivanich K, Looareesuwan S, et al. (2007) Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae. Antimicrob Agents Chemother 51: 3523–3530. doi: 10.1128/aac.00234-07

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133