| [1] | Ferrer-Vaquer A, Viotti M, Hadjantonakis AK (2010) Transitions between epithelial and mesenchymal states and the morphogenesis of the early mouse embryo. Cell Adh Migr 4: 447–457.
|
| [2] | Hay ED (2005) The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Developmental Dynamics 233: 706–720.
|
| [3] | Shook D, Keller R (2003) Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev 120: 1351–1383.
|
| [4] | Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nature Reviews Cancer 2: 442–454.
|
| [5] | Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646–674.
|
| [6] | Lee JM, Dedhar S, Kalluri R, Thompson EW (2006) The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 172: 973–981.
|
| [7] | Buckley ST, Medina C, Davies AM, Ehrhardt C (2012) Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis. Nanomedicine 8: 355–364.
|
| [8] | Thoelking G, Reiss B, Wegener J, Oberleithner H, Pavenstaedt H, et al. (2010) Nanotopography follows force in TGF-beta1 stimulated epithelium. Nanotechnology 21: 265102.
|
| [9] | Nieto MA (2009) Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives. International Journal of Developmental Biology 53: 1541–1547.
|
| [10] | Venkov C, Plieth D, Ni T, Karmaker A, Bian AH, et al. (2011) Transcriptional Networks in Epithelial-Mesenchymal Transition. Plos One 6.
|
| [11] | Morris CE, Homann U (2001) Cell surface area regulation and membrane tension. J Membr Biol 179: 79–102.
|
| [12] | Fletcher DA, Mullins D (2010) Cell mechanics and the cytoskeleton. Nature 463: 485–492.
|
| [13] | Janmey PA, McCulloch CA (2007) Cell mechanics: Integrating cell responses to mechanical stimuli. Annual Review of Biomedical Engineering 9: 1–34.
|
| [14] | Krieg M, Arboleda-Estudillo Y, Puech PH, Kafer J, Graner F, et al. (2008) Tensile forces govern germ-layer organization in zebrafish. Nature Cell Biology 10: 429–U122.
|
| [15] | Maruthamuthu V, Sabass B, Schwarz US, Gardel ML (2011) Cell-ECM traction force modulates endogenous tension at cell-cell contacts. Proc Natl Acad Sci U S A 108: 4708–4713.
|
| [16] | Zhu C, Bao G, Wang N (2000) Cell mechanics: mechanical response, cell adhesion, and molecular deformation. Annual Review of Biomedical Engineering 2: 189–226.
|
| [17] | Groulx N, Boudreault F, Orlov SN, Grygorczyk R (2006) Membrane reserves and hypotonic cell swelling. Journal of Membrane Biology 214: 43–56.
|
| [18] | Sinha B, Koster D, Ruez R, Gonnord P, Bastiani M, et al. (2011) Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae. Cell 144: 402–413.
|
| [19] | Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. Journal of Clinical Investigation 119: 1420–1428.
|
| [20] | Evans EA, Waugh R, Melnik L (1976) Elastic Area Compressibility Modulus of Red-Cell Membrane. Biophysical Journal 16: 585–595.
|
| [21] | Mahaffy RE, Shih CK, MacKintosh FC, Kas J (2000) Scanning probe-based frequency-dependent microrheology of polymer gels and biological cells. Physical Review Letters 85: 880–883.
|
| [22] | Haynes J, Srivastava J, Madson N, Wittmann T, Barber DL (2011) Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell 22: 4750–4764.
|
| [23] | Lamouille S, Derynck R (2007) Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 178: 437–451.
|
| [24] | Schneider-Poetsch T, Ju JH, Eyler DE, Dang YJ, Bhat S, et al. (2010) Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nature Chemical Biology 6: 209–217.
|
| [25] | Kovacs M, Toth J, Hetenyi C, Malnasi-Csizmadia A, Sellers JR (2004) Mechanism of blebbistatin inhibition of myosin II. Journal of Biological Chemistry 279: 35557–35563.
|
| [26] | Ishizaki T, Uehata M, Tamechika I, Keel J, Nonomura K, et al. (2000) Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 57: 976–983.
|
| [27] | Schneider D, Janshoff A (2012) Inhibition of actin dynamics during epithelial-to-mesenchymal transition. Biochemical and Biophysical Research Communications 419: 221–225.
|
| [28] | Sen S, Subramanian S, Discher DE (2005) Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments. Biophys J 89: 3203–3213.
|
| [29] | Pietuch A, Bruckner BR, Janshoff A (2013) Membrane tension homeostasis of epithelial cells through surface area regulation in response to osmotic stress. Biochim Biophys Acta 1833: 712–722.
|
| [30] | Pietuch A, Brückner BR, Fine T, Mey I, Janshoff A (2013). Soft Matter, doi: 10.1039/C3SM51610E.
|
| [31] | Lomakina EB, Spillmann CM, King MR, Waugh RE (2004) Rheological analysis and measurement of neutrophil indentation. Biophysical Journal 87: 4246–4258.
|
| [32] | Williams TJ, Homer LD, Shafer JA, Goldstein IJ, Garegg PJ, et al. (1981) Characterization of the extended carbohydrate binding site of concanavalin A: specificity for interaction with the nonreducing termini of alpha-(1 leads to 2)-linked disaccharides. Arch Biochem Biophys 209: 555–564.
|
| [33] | Sheetz MP (2001) Cell control by membrane-cytoskeleton adhesion. Nat Rev Mol Cell Biol 2: 392–396.
|
| [34] | Dai J, Sheetz MP (1999) Membrane tether formation from blebbing cells. Biophys J 77: 3363–3370.
|
| [35] | Krieg M, Helenius J, Heisenberg CP, Muller DJ (2008) A bond for a lifetime: employing membrane nanotubes from living cells to determine receptor-ligand kinetics. Angew Chem Int Ed Engl 47: 9775–9777.
|
| [36] | Engin S, Trouillet V, Franz CM, Welle A, Bruns M, et al. (2010) Benzylguanine thiol self-assembled monolayers for the immobilization of SNAP-tag proteins on microcontact-printed surface structures. Langmuir 26: 6097–6101.
|
| [37] | Alcaraz J, Buscemi L, Grabulosa M, Trepat X, Fabry B, et al. (2003) Microrheology of human lung epithelial cells measured by atomic force microscopy. Biophysical Journal 84: 2071–2079.
|
| [38] | Roca-Cusachs P, Almendros I, Sunyer R, Gavara N, Farre R, et al. (2006) Rheology of passive and adhesion-activated neutrophils probed by atomic force microscopy. Biophysical Journal 91: 3508–3518.
|
| [39] | Alcaraz J, Buscemi L, Puig-de-Morales M, Colchero J, Baro A, et al. (2002) Correction of microrheological measurements of soft samples with atomic force microscopy for the hydrodynamic drag on the cantilever. Langmuir 18: 716–721.
|
| [40] | Oliver WC, Pharr GM (2004) Measurement of hardness and elastic modulus by instrumented indentation: Advances in understanding and refinements to methodology. Journal of Materials Research 19: 3–20.
|
| [41] | Hutter JL, Bechhoefer J (1993) Calibration of Atomic-Force Microscope Tips. Review of Scientific Instruments 64: 1868–1873.
|
| [42] | Brown KA, Aakre ME, Gorska AE, Price JO, Eltom SE, et al. (2004) Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Res 6: R215–231.
|
| [43] | Pietuch A, Janshoff A (2013) Mechanics of spreading cells probed by atomic force microscopy. Open Biol 3: 130084.
|
| [44] | Larson SM, Lee HJ, Hung PH, Matthews LM, Robinson DN, et al. (2010) Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins. Mol Biol Cell 21: 3182–3192.
|
| [45] | Hochmuth RM, Shao JY, Dai JW, Sheetz MP (1996) Deformation and flow of membrane into tethers extracted from neuronal growth cones. Biophysical Journal 70: 358–369.
|
| [46] | Hochmuth RM, Evans EA (1982) Extensional flow of erythrocyte membrane from cell body to elastic tether. I. Analysis. Biophys J 39: 71–81.
|
| [47] | Marcus WD, Hochmuth RM (2002) Experimental studies of membrane tethers formed from human neutrophils. Ann Biomed Eng 30: 1273–1280.
|
| [48] | Sun M, Northup N, Marga F, Huber T, Byfield FJ, et al. (2007) The effect of cellular cholesterol on membrane-cytoskeleton adhesion. J Cell Sci 120: 2223–2231.
|
| [49] | Shroff SG, Saner DR, Lal R (1995) Dynamic Micromechanical Properties of Cultured Rat Atrial Myocytes Measured by Atomic-Force Microscopy. American Journal of Physiology-Cell Physiology 269: C286–C292.
|
| [50] | Kollmannsberger P, Fabry B (2009) Active soft glassy rheology of adherent cells. Soft Matter 5: 1771–1774.
|
| [51] | Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, et al. (2001) Scaling the microrheology of living cells. Physical Review Letters 87.
|
| [52] | Wendt MK, Taylor MA, Schiemann BJ, Schiemann WP (2011) Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer. Molecular Biology of the Cell 22: 2423–2435.
|
| [53] | Maeda M, Johnson KR, Wheelock MJ (2005) Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J Cell Sci 118: 873–887.
|
| [54] | Cavey M, Lecuit T (2009) Molecular bases of cell-cell junctions stability and dynamics. Cold Spring Harb Perspect Biol 1: a002998.
|
| [55] | Bayas MV, Leung A, Evans E, Leckband D (2006) Lifetime measurements reveal kinetic differences between homophilic cadherin bonds. Biophys J 90: 1385–1395.
|
| [56] | Bajpai S, Feng Y, Krishnamurthy R, Longmore GD, Wirtz D (2009) Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J Biol Chem 284: 18252–18259.
|
| [57] | Evans EA, Calderwood DA (2007) Forces and bond dynamics in cell adhesion. Science 316: 1148–1153.
|
| [58] | Fine T, Mey I, Rommel C, Wegener J, Steinem C, et al. (2009) Elasticity mapping of apical cell membranes. Soft Matter 5: 3262–3265.
|
| [59] | Piek E, Moustakas A, Kurisaki A, Heldin CM, ten Dijke P (1999) TGF-beta type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. Journal of Cell Science 112: 4557–4568.
|
| [60] | Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, et al. (2005) Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 307: 1603–1609.
|
| [61] | Bianchi A, Gervasi ME, Bakin A (2010) Role of beta5-integrin in epithelial-mesenchymal transition in response to TGF-beta. Cell Cycle 9: 1647–1659.
|
| [62] | Hills CE, Siamantouras E, Smith SW, Cockwell P, Liu KK, et al. (2012) TGFbeta modulates cell-to-cell communication in early epithelial-to-mesenchymal transition. Diabetologia 55: 812–824.
|
| [63] | Shirakihara T, Saitoh M, Miyazono K (2007) Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta. Mol Biol Cell 18: 3533–3544.
|
| [64] | Janda E, Nevolo M, Lehmann K, Downward J, Beug H, et al. (2006) Raf plus TGF beta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene 25: 7117–7130.
|
| [65] | Tian XR, Liu ZL, Niu B, Zhang JL, Tan TK, et al. (2011) E-Cadherin/beta-Catenin Complex and the Epithelial Barrier. Journal of Biomedicine and Biotechnology
|
| [66] | Schneider D, Tarantola M, Janshoff A (2011) Dynamics of TGF-beta induced epithelial-to-mesenchymal transition monitored by Electric Cell-Substrate Impedance Sensing. Biochim Biophys Acta 1813: 2099–2107.
|
| [67] | Boulant S, Kural C, Zeeh JC, Ubelmann F, Kirchhausen T (2011) Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nature Cell Biology 13: 1124–U1158.
|
| [68] | Dai J, Ting-Beall HP, Sheetz MP (1997) The secretion-coupled endocytosis correlates with membrane tension changes in RBL 2H3 cells. J Gen Physiol 110: 1–10.
|
| [69] | Paluch E, Heisenberg CP (2009) Biology and physics of cell shape changes in development. Current Biology 19: R790–799.
|
| [70] | Raucher D, Sheetz MP (2000) Cell spreading and lamellipodial extension rate is regulated by membrane tension. J Cell Biol 148: 127–136.
|
| [71] | Schafer E, Kliesch TT, Janshoff A (2013) Mechanical Properties of Giant Liposomes Compressed between Two Parallel Plates: Impact of Artificial Actin Shells. Langmuir
|
| [72] | Roubinet C, Decelle B, Chicanne G, Dorn JF, Payrastre B, et al. (2011) Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis. Journal of Cell Biology 195: 99–112.
|
| [73] | Sekyrova P, Ostblom J, Andang M (2012) Blebbing as a physical force in cancer EMT - Parallels with mitosis. Seminars in Cancer Biology 22: 369–373.
|
| [74] | Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, et al. (2003) Time scale and other invariants of integrative mechanical behavior in living cells. Physical Review E 68.
|
| [75] | Jones WR, Ting-Beall HP, Lee GM, Kelley SS, Hochmuth RM, et al. (1999) Alterations in the Young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. Journal of Biomechanics 32: 119–127.
|
| [76] | Huang RY, Guilford P, Thiery JP (2012) Early events in cell adhesion and polarity during epithelial-mesenchymal transition. J Cell Sci 125: 4417–4422.
|
| [77] | McGrail DJ, Ghosh D, Quach ND, Dawson MR (2012) Differential Mechanical Response of Mesenchymal Stem Cells and Fibroblasts to Tumor-Secreted Soluble Factors. Plos One 7.
|
| [78] | Batchelder EL, Hollopeter G, Campillo C, Mezanges X, Jorgensen EM, et al. (2011) Membrane tension regulates motility by controlling lamellipodium organization. Proc Natl Acad Sci U S A 108: 11429–11434.
|
| [79] | Diz-Munoz A, Krieg M, Bergert M, Ibarlucea-Benitez I, Muller DJ, et al. (2010) Control of directed cell migration in vivo by membrane-to-cortex attachment. PLoS Biol 8: e1000544.
|
| [80] | Liu LH, Parent CA (2011) TOR kinase complexes and cell migration. Journal of Cell Biology 194: 815–824.
|
| [81] | Darenfed H, Dayanandan B, Zhang T, Hsieh SHK, Fournier AE, et al. (2007) Molecular characterization of the effects of Y-27632. Cell Motility and the Cytoskeleton 64: 97–109.
|
