Objectives To investigate the effects of various measures of prenatal care on adverse pregnancy outcomes in women with a history of infertility. Study Design A retrospective cohort study. Methods Data were derived by linking 2 large nationwide population-based datasets, the National Health Insurance Research Database and Taiwan Birth Certificate Registry. The study sample included 15,056 women with an infertility diagnosis and 60,224 randomly selected women without infertility matched to the study sample by maternal age. A conditional logistic regression analysis was performed for the analysis. Results Women diagnosed with infertility respectively had 1.39 (95% CI, 1.06~1.83), 1.15 (95% CI, 1.08~1.24), 1.13 (95% CI, 1.08~1.18), and 1.08 (95% CI, 1.05~1.12) higher odds of having very low birth weight (VLBW) babies, preterm births, labor complications, and cesarean sections (CSs) compared to women without infertility. Inadequate numbers of total and major prenatal visits and late initiation of prenatal care increased the risks of adverse pregnancy outcomes in women with infertility, especially the risk of a VLBW baby. However, no significant associations were found for the risks of adverse birth outcomes in infertile women with adequate prenatal care compared to fertile women with adequate care. Conclusions Study findings suggest that adequate prenatal care can reduce the risk of adverse pregnancy outcomes in women with infertility.
References
[1]
Raatikainen K, Heiskanen N, Heinonen S (2007) Under-attending free antenatal care is associated with adverse pregnancy outcomes. BMC Public Health 7: 268. doi:10.1186/1471-2458-7-268. PubMed: 17900359.
[2]
Heaman MI, Newburn-Cook CV, Green CG, Elliott LJ, Helewa ME (2008) Inadequate prenatal care and its association with adverse pregnancy outcomes: a comparison of indices. BMC Pregnancy Childbirth 8: 15. doi:10.1186/1471-2393-8-15. PubMed: 18452623.
[3]
Cox RG, Zhang L, Zotti ME, Graham J (2011) Prenatal care utilization in Mississippi: racial disparities and implications for unfavorable birth outcomes. Matern Child Health J 15: 931-942. doi:10.1007/s10995-009-0542-6. PubMed: 19943096.
[4]
Partridge S, Balayla J, Holcroft CA, Abenhaim HA (2012) Inadequate Prenatal Care Utilization and Risks of Infant Mortality and Poor Birth Outcome: A Retrospective Analysis of 28,729,765 U.S. Deliveries over 8 Years. Am J Perinatol.
[5]
Segev Y, Riskin-Mashiah S, Lavie O, Auslender R (2011) Assisted reproductive technologies: medical safety issues in the older woman. J Womens Health (Larchmt) 20: 853-861. doi:10.1089/jwh.2010.2603. PubMed: 21510806.
[6]
Liu K, Case A (2011) Advanced reproductive age and fertility. J Obstet Gynaecol Can 33: 1165-1175. PubMed: 22082792.
[7]
Basso O, Baird DD (2003) Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort. Hum Reprod 18: 2478-2484. doi:10.1093/humrep/deg444. PubMed: 14585905.
[8]
Thomson F, Shanbhag S, Templeton A, Bhattacharya S (2005) Obstetric outcome in women with subfertility. BJOG 112: 632-637. doi:10.1111/j.1471-0528.2004.00489.x. PubMed: 15842289.
[9]
Schieve LA, Cohen B, Nannini A, Ferre C, Reynolds MA et al. (2007) A population-based study of maternal and perinatal outcomes associated with assisted reproductive technology in Massachusetts. Matern Child Health J 11: 517-525. doi:10.1007/s10995-007-0202-7. PubMed: 17345154.
[10]
Welmerink DB, Voigt LF, Daling JR, Mueller BA (2010) Infertility treatment use in relation to selected adverse birth outcomes. Fertil Steril 94: 2580-2586. doi:10.1016/j.fertnstert.2010.03.005. PubMed: 20434152.
[11]
Wehby GL, Murray JC, Castilla EE, Lopez-Camelo JS, Ohsfeldt RL (2009) Prenatal care effectiveness and utilization in Brazil. Health Policy Plan 24: 175-188. doi:10.1093/heapol/czp005. PubMed: 19282483.
[12]
Krans EE, Davis MM (2012) Preventing Low Birthweight: 25 years, prenatal risk, and the failure to reinvent prenatal care. Am J Obstet Gynecol 206: 398-403. doi:10.1016/j.ajog.2011.06.082. PubMed: 21889122.
[13]
Alexander GR, Kotelchuck M (2001) Assessing the role and effectiveness of prenatal care: history, challenges, and directions for future research. Public Health Rep 116: 306-316. doi:10.1093/phr/116.4.306. PubMed: 12037259.
[14]
Chen LM, Wen SW, Li CY (2001) The impact of national health insurance on the utilization of health care services by pregnant women: the case in Taiwan. Matern Child Health J 5: 35-42. doi:10.1023/A:1011345801673. PubMed: 11341718.
[15]
D.O.H. (2010) Maternal Health Handbook. In: Bureau of Health Promotion DoH. Taipei, Taiwan R.O.C.
[16]
Kotelchuck M (1994) An evaluation of the Kessner Adequacy of Prenatal Care Index and a proposed Adequacy of Prenatal Care Utilization Index. Am J Public Health 84: 1414-1420. doi:10.2105/AJPH.84.9.1414. PubMed: 8092364.
[17]
Kitsantas P, Gaffney KF, Cheema J (2012) Life Stressors and Barriers to Timely Prenatal Care for Women with High-Risk Pregnancies Residing in Rural and Nonrural Areas. Womens Health Issues, 22: e455–60. PubMed: 22841802.
[18]
Beeckman K, Louckx F, Masuy-Stroobant G, Downe S, Putman K (2011) The development and application of a new tool to assess the adequacy of the content and timing of antenatal care. BMC Health Serv Res 11: 213. doi:10.1186/1472-6963-11-213. PubMed: 21896201.
[19]
Kogan MD, Alexander GR, Kotelchuck M, Nagey DA (1994) Relation of the content of prenatal care to the risk of low birth weight. Maternal reports of health behavior advice and initial prenatal care procedures. JAMA 271: 1340-1345. doi:10.1001/jama.1994.03510410052032. PubMed: 8158819.
[20]
Ludwig AK, Katalinic A, Steinbicker V, Diedrich K, Ludwig M (2006) Antenatal care in singleton pregnancies after ICSI as compared to spontaneous conception: data from a prospective controlled cohort study in Germany. Hum Reprod 21: 713-720. PubMed: 16311297.
[21]
Herbert DL, Lucke JC, Dobson AJ (2012) Birth outcomes after spontaneous or assisted conception among infertile Australian women aged 28 to 36 years: a prospective, population-based study. Fertil Steril 97: 630-638. doi:10.1016/j.fertnstert.2011.12.033. PubMed: 22265037.
[22]
Cooper AR, O'Neill KE, Allsworth JE, Jungheim ES, Odibo AO et al. (2011) Smaller fetal size in singletons after infertility therapies: the influence of technology and the underlying infertility. Fertil Steril 96: 1100-1106. doi:10.1016/j.fertnstert.2011.08.038. PubMed: 21944928.
[23]
Raatikainen K, Kuivasaari-Pirinen P, Hippel？inen M, Heinonen S (2012) Comparison of the pregnancy outcomes of subfertile women after infertility treatment and in naturally conceived pregnancies. Hum Reprod 27: 1162-1169. doi:10.1093/humrep/des015. PubMed: 22333986.
[24]
Pandian Z, Bhattacharya S, Templeton A (2001) Review of unexplained infertility and obstetric outcome: a 10 year review. Hum Reprod 16: 2593-2597. doi:10.1093/humrep/16.12.2593. PubMed: 11726580.
[25]
Romundstad LB, Romundstad PR, Sunde A, von Düring V, Skjaerven R et al. (2008) Effects of technology or maternal factors on perinatal outcome after assisted fertilisation: a population-based cohort study. Lancet 372: 737-743. doi:10.1016/S0140-6736(08)61041-7. PubMed: 18674812.
[26]
Hayashi M, Nakai A, Satoh S, Matsuda Y (2012) Adverse obstetric and perinatal outcomes of singleton pregnancies may be related to maternal factors associated with infertility rather than the type of assisted reproductive technology procedure used. Fertil Steril, 98: 922–8. PubMed: 22763098.
[27]
McDonald SD, Han Z, Mulla S, Murphy KE, Beyene J et al. (2009) Preterm birth and low birth weight among in vitro fertilization singletons: a systematic review and meta-analyses. Eur J Obstet Gynecol Reprod Biol 146: 138-148. doi:10.1016/j.ejogrb.2009.05.035. PubMed: 19577836.
[28]
Dhont M, De Sutter P, Ruyssinck G, Martens G, Bekaert A (1999) Perinatal outcome of pregnancies after assisted reproduction: a case-control study. Am J Obstet Gynecol 181: 688-695. doi:10.1016/S0002-9378(99)70514-4. PubMed: 10486485.
[29]
Wen J, Jiang J, Ding C, Dai J, Liu Y, et al. (2012) Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis. Fertil Steril 97: 1331-1337 e1331-1334.
[30]
Zhu JL, Basso O, Obel C, Bille C, Olsen J (2006) Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ 333: 679. Available online at: doi:10.1136/bmj.38919.495718.AE. PubMed: 16893903.
[31]
Davies MJ, Moore VM, Willson KJ, Van Essen P, Priest K et al. (2012) Reproductive technologies and the risk of birth defects. N Engl J Med 366: 1803-1813. doi:10.1056/NEJMoa1008095. PubMed: 22559061.
[32]
Herbst MA, Mercer BM, Beazley D, Meyer N, Carr T (2003) Relationship of prenatal care and perinatal morbidity in low-birth-weight infants. Am J Obstet Gynecol 189: 930-933. doi:10.1067/S0002-9378(03)01055-X. PubMed: 14586328.
[33]
Petrou S, Kupek E, Vause S, Maresh M (2003) Antenatal visits and adverse perinatal outcomes: results from a British population-based study. Eur J Obstet Gynecol Reprod Biol 106: 40-49. doi:10.1016/S0301-2115(02)00215-4. PubMed: 12475580.
[34]
Lin HC, Chen YH, Lee HC (2009) Prenatal care and adverse pregnancy outcomes among women with schizophrenia: a nationwide population-based study in Taiwan. J Clin Psychiatry 70: 1297-1303. doi:10.4088/JCP.09m05087. PubMed: 19818245.
[35]
Chung K, Coutifaris C, Chalian R, Lin K, Ratcliffe SJ et al. (2006) Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization. Fertil Steril 86: 1634–1641. doi:10.1016/j.fertnstert.2006.04.038. PubMed: 17074345.
[36]
Reddy UM, Wapna RJ, Rebar RW, Tasca RJ (2007) Infertility, assisted reproductive technology, and adverse pregnancy outcomes: executive summary of a national institute of child health and human development workshop. Obstet Gynecol 109: 967-977. doi:10.1097/01.AOG.0000259316.04136.30. PubMed: 17400861.
[37]
Brown SJ, Yelland JS, Sutherland GA, Baghurst PA, Robinson JS (2011) Stressful life events, social health issues and low birthweight in an Australian population-based birth cohort: challenges and opportunities in antenatal care. BMC Public Health 11: 196. doi:10.1186/1471-2458-11-196. PubMed: 21450106.
