Association between Pretreatment Levels of Serum Vascular Endothelial Growth Factor (VEGF) and Survival Outcomes in Locally Advanced Cervical Cancer Patients
Objective: To evaluate the association between
pretreatment levels of serum vascular endothelial growth factor (VEGF) and
long-term treatment outcomes in patients with locally advanced cervical cancer
(LACC). Methods: Thirty-nine
patients diagnosed with LACC (stage IIB-IVA) and obtaining blood for serum VEGF were identified. All patients received complete
treatment as radical radiotherapy with or without concurrent chemotherapy.
Surveillance for all patients was every 3 months during the first 2 years, and
every 6 months later. Results: Mean age of 39 patients was 52.3 ± 10.8
years old. Twenty-three
patients (59.0%) had stage IIB, and 16 patients (41.0%) had stage IIIB. Histological
cell type was mostly squamous cell carcinoma (89.7%). The median and 75th percentile level of serum VEGF were 610.2 pg/ml (0.0 - 4067.2 pg/ml) and 825.6
pg/ml, respectively. At median follow-up of 37.0 months (range, 26.8-46.3 months), the 3-year OS rate was
78.6%. Clinical stage (p=0.04) and 75th percentile of VEGF level (p=0.04) were impacted
on OS in univariable analysis. The 3-year OSof patients in stage IIB with serum VEGF
of ≤825.6 pg/ml and
of > 825.6 pg/ml was slightly different,
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