A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study
A candidate identification questionnaire
(CIQ) was tested to determine its predictive value for patient-reported satisfaction in patients switched from once-weekly
or once-daily treatment with a bisphosphonate to once-monthly dosing. This was a
prospective, open-label, multicenter international study in patients with postmenopausal
osteoporosis who had been receiving once-daily or once-weekly alendronate or risendronate
for at least 3 months. Patients completed
a CIQ, then commenced 150 mg monthly ibandronate for 6 months. Patients completed the Osteoporosis Patient Satisfaction Questionnaire (OPSAT-QTM)
at baseline for 6 months. Scores were converted to composite satisfaction scores
(CSS, scale 0-100). Totally 677 patients completed a CIQ, 645 were enrolled in
the treatment phase and comprised the intent-to-treat (ITT) population, and 630
completed the study. In the ITT population, 68.1% patients answered “yes” to one
or more CIQ questions. OPSAT-Q scores increased for the convenience, quality of
life and overall satisfaction domains (p < 0.001). Decreases in scores for the side effects
domains were significant (p < 0.001) in the CIQ “yes” group, but not for the
degree of bother (decrease in mean of 0.1 points, p = 0.50) or duration (no change,
p = 0.84) of non-gastrointestinal side effects. Of 638 patients who completed the
preference questionnaire, 93.0% of patients preferred
the once-monthly dosing schedule and 563 patients (90.7%) found it more
convenient. The most common adverse events were dyspepsia (1.9%), nausea (1.1%),
and upper abdominal pain (0.9%). Patients are likely to prefer treatment with
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