This prospective study was undertaken to ascertain the
incidence, histology and pathological features of different types of
asymptomatic or sub clinical prostatic diseases.Prostate glands
were obtained from 79 consecutive adult males aged 30 years and above who died
from non-prostate related diseases at the University College Hospital Ibadan
over an eighteen months period. The glands were weighed and fixed in 10% neutral buffered
formalin. The sampling method of the prostate gland described by Vainer et al. (2011) was employed in this study. Paraffin-embedded sections were
stained with haematoxylin and eosin and were systematically examined for focal
prostate disease.The patients’ ages ranged from 30 to 86 years. The most common
lesions were nodular hyperplasia (81%), followed by adenocarcinoma (6.3%).
Three cases (3.8%) had schistosomiasis. Adenocarcinoma and nodular hyperplasia
occurred in relatively older patients than those with normal glands or chronic
prostatitis/schistosomiasis (p = 0.05). There was an increase in weight of the
prostate with age (p < 0.001) and normal prostate glands weighed
significantly less than diseased glands (p = 0.02). Focal prostatic atrophy was
observed in 24.1% and metaplastic changes were observed in eight (10.1%) of the
cases. Prostatic intraepithelial neoplasia (PIN) was not seen in any case, not
even amongst the adenocarcinomas.The low frequency of prostatic adenocarcinoma
and the absence of high grade prostatic intraepithelial neoplasia in this study
despite the observation of increasing number of prostatic carcinoma required further
investigation. Schistosomiasis was also found to be present in the adult male
population.
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