Long-term Survivors of Adult Rhabdomyosarcoma of Maxillary Sinus Following Multimodal Therapy: Case Reports and Literature Reviews

Rhabdomyosarcoma of the maxillary sinus is uncommon in adults. The clinical courseand appropriate treatment strategy for the disease remains to be elucidated. This articledescribes two adult patients with rhabdomyosarcoma of the maxillary sinus who achievedlong-term survival after undergoing multimodal therapy. We also reviewed the literatureregarding 23 patients who were 15 years of age or older and had rhabdomyosarcoma of themaxillary sinus and were treated between 1950 and 2000. Results of our analysis suggestthat multimodal therapy may become the mainstay treatment for adult rhabdomyosarcoma ofthe maxillary sinus. We believe that adequate surgical procedures, planned radiotherapy,aggressive chemotherapeutic agents and the best supportive care for complications mayimprove the prognosis of patients with this disease.