A Case of Gastrointestinal Stromal Tumor with Hyperinsulinemic Hypoglycemia

Gastrointestinal stromal tumor (GIST) is an uncommon malignant tumor that hasrecently been drawn to the attention of clinicians because of the protean clinical spectrum,endocrinological pathogenesis, aggressive metastatic features, poor prognosis, oncogenictyrosine kinase receptor mutation and its brilliant revolutionized inhibitor imatinib.However, very few cases of GIST and hypoglycemia have been reported worldwide andthey are usually associated with normal or low insulin levels. Here, we report on a rare caseof GIST with postabsorptive hypoglycemia, extraordinary hyperinsulinemia and low insulinlikegrowth factor I (IGF-I). Its unusual neurological presentation made its diagnosis verydifficult. After a complete resection, the symptoms diminished. We point out the unusualendogenous hyperinsulinism, clinical features and postulate possible mechanisms.