Pregnancy in Premature Ovarian Failure after Therapy Using Chinese Herbal Medicine.

We present ovulation that occurred after the administration of traditional Chinese herbalmedicine for 3 months in a woman with premature ovarian failure (POF) and secondaryamenorrhea for 8 years. Traditional Chinese medicine concentrated herbal extracts ofcooked rehmannia, Chinese yam, wolfberry fruit, dogwood fruit, cyathula root, dodder seed,antler glue, tortoise-plastron glue, epimedium and morinda root were prescribed, which werea modification of the herbal formula Zuo-gui-wan. When the patient discontinued theChinese herbal medicine treatment and tried therapy with clomiphene citrate, neither ovulationnor conception occurred. Eight months after beginning clomiphene citrate therapy, theconcentrations of follicle stimulating hormone and luteinizing hormone were still in thepostmenopausal range. The modified formula of Zuo-gui-wan was prescribed again and thepatient conceived 1 month after taking Zuo-gui-wan. Thus, we suggested that Chinese herbalmedicine restored ovarian function effectively and promptly, and offers another option fortreating infertility in patients with POF.