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A Comparison of Clinicopathological Features and Molecular Markers in British and Nigerian Women with Breast Cancer

Keywords: breast cancer , nigerian , immunocytochemistry , molecular markers

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Abstract:

Background: Some studies have suggested that breast cancer in black women is more aggressive than in white women. This study’s aim was to look for evidence of differences in tumour biology between the two cohorts.Methods: This study compared the stage, grade and pathological expression of ve immunohistochemical markers (oestrogen receptor [ER], progesterone receptor [PR], ERBB2, P53 and cyclin D1 [CCND1]) in tumour biopsies from age-matched cohorts of patients from Nigeria and England. Sixty-eight suitable samples from Nigerian (n = 34) and British (n = 34) breast cancer patients were retrieved from histology tissue banks.Results: There were signi cant differences between the two cohorts in the expression of ER and CCND1; and stark differences in the clinical stage at presentation. But no signi cant differences were observed for tumour grade.Conclusion: There was a signi cantly, low ER expression in the Nigerian cases which also predicts a poor response to hormonal therapy as well as a poorer prognosis. Differences in clinical stage at presentation will most likely in uence prognosis between Nigerian and British women with breast cancer

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