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A coenzima Q10 produz efeito sobre a preven o da miringoesclerose?: Estudo experimental com ratos Is there any effect of coenzyme Q10 on prevention of myringosclerosis?: Experimental study with rats

Keywords: antioxidantes , esclerose , membrana timpanica , antioxidants , sclerosis , tympanic membrane

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Abstract:

Estudos recentes demonstram que a forma o de miringoesclerose pode ser reduzida pela aplica o de enzimas e elementos antioxidantes. OBJETIVO: Investigar a eficácia da coenzima Q10 na preven o de miringoesclerose experimentalmente induzida. MéTODO: Quarenta e oito ratas Wistar albinas saudáveis sofreram miringotomia e foram divididas aleatoriamente em quatro grupos. O Grupo A n o recebeu tratamento algum; o Grupo B recebeu coenzima Q10 por via oral; o Grupo C foi tratado com soro fisiológico tópico; e o Grupo D recebeu coenzima Q10 tópica. No 15o dia de tratamento, as membranas timpanicas foram examinadas por otomicroscopia. As les es miringoescleróticas foram documentadas de forma semiquantitativa por meio de uma escala de quatro pontos. Após a coleta, as membranas timpanicas foram avaliadas por histopatologia. RESULTADOS: No grupo D (coenzima Q10 tópica) foi observada a ocorrência de otite nos primeiros quatro dias do estudo, o que levou à sua exclus o do estudo. O exame de otomicroscopia n o revelou diferen as significativas entre grupos em termos de forma o de miringoesclerose (p = 0,241). Diferen as estatisticamente significativas foram observada quando os exames histopatológicos do grupo A foram comparados aos dos grupos B e C (p = 0,004; p < 0,001, respectivamente). N o houve diferen a significativa entre os grupos B e C (p = 0,160). CONCLUS O: A administra o oral de coenzima Q10 n o reduziu a forma o de miringoesclerose nos ratos submetidos à miringotomia. Recent studies have shown that the formation of myringosclerosis could be reduced by the application of antioxidant enzymes and elements. OBJECTIVE: The aim of this study was to investigate the effectiveness of coenzyme Q10 on the prevention of experimentally induced myringosclerosis. METHOD: Forty-eight healthy female wistar albino rats were bilaterally myringotomized and divided into four groups randomly. Group A received no treatment, group B was administered oral coenzyme Q10. Group C was treated with topical saline solution, group D received topically coenzyme Q10. On the 15th day of treatment, tympanic membranes were examined by otomicroscopy. Myringosclerotic lesions were documented semiquantitatively by using 4-point scale. After harvesting tympanic membranes were evaluated histopathologically. RESULTS: In group D (topical coenzyme Q10), we observed otitis within the first four days of the study and this group was excluded from the study. Regarding otomicroscopic examinations, there were no significant differences among groups in myringosclerosis formation (p = 0.241). When group

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