Multi-Glycomics Platform Approach for Cancer

Diseases as diverse as infection and cancer are known to involve changes in glycosylation. Therefore, systematic approach to monitor glycosylation based on specific glycan types are necessary for reliable biomarker discovery and better understanding of biological function implicated with glycans. In this study, we developed the method to enrich a specific class of glycans such as mannose and sialic acid and monitor the changes in cancers. Several glycans are identified as cancer specific.