Critical appraisal of clinicopathological features of anaplastic carcinoma small intestine – A rare case report

Anaplastic carcinoma is an extremely rare variant of small intestine adenocarcinoma with only an occasional case having been reported in literature to date. We report a case of 46 year old male who presented with an endophytic tumor in ileum extending through full thickness of intestinal wall, with invasion into mesenteric fat. Microscopically, the tumor showed a biphasic growth pattern unlike conventional adenocarcinoma. The present case discusses the histomorphology of anaplastic carcinoma small intestine, its histochemical and immunohistochemical profile and the differential diagnosis of this rare but highly aggressive pathological entity.