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印记基因Igf2r和RB-1在代谢综合征不孕患者子宫内膜表达水平的研究
Expression of Imprinted Genes Igf2r and RB-1 in the Endometrium of Infertile Women with Metabolic Syndrome

DOI: 10.12677/ACM.2012.24006, PP. 27-31

Keywords: 印迹基因;Igf2r;RB-1;代谢综合征
Imprinted Genes
, Igf2r, RB-1, Metabolic Syndrome

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Abstract:

目的:研究印记基因Igf2rRB-1在代谢综合征(MS)不孕患者子宫内膜的表达。方法:选择20117月至201112月因不孕症来我院生殖中心就诊的MS患者11例作为实验组,代谢正常女性15例作为对照组,收集分泌期的子宫内膜组织,采用实时定量聚合酶链反应方法(RT-PCR)测定子宫内膜组织Igf2rRB-1的表达水平。结果Igf2rRB-1MS患者和代谢正常妇女子宫内膜中均有表达,与正常女性相比较,MS患者子宫内膜Igf2r

References

[1]  Y. Linne. Effects of obesity on women reproduction and com- plications during pregnancy. Obesity Reviews, 2004, 5(3): 137- 143.
[2]  F. Hall, A. Neubert. Obesity and pregnancy. Obstetrical & Gynecological Survey, 2005, 60(4): 253-260.
[3]  M. Mitchell, D. T. Armstrong, R. L. Robker, et al. Adipokines: Implications for female fertility and obesity. Reproduction, 2005, 130(5): 583-597.
[4]  J. Bellver, M. A. Melo, E. Bosch, et al. Obesity and poor repro- ductive outcome: The potential role of the endometrium. Fertility and Sterility, 2007, 88( 2): 446-451
[5]  A. Naumova, C. Sapienza. The genetics of retinoblastoma, re- visited. American Journal of Human Genetics, 1994, 54(2): 264- 273.
[6]  R. G. Edwards. Genetics, epigenetics and gene silencing in dif- ferentiating mammalian embryos. Reproductive BioMedicine On- line, 2006, 13(5): 732-753.
[7]  P. E. Szabó, J. R. Mann. Allele-specific expression and total ex- pression levels of imprinted genes during early mouse develop- ment: Implications for imprinting mechanisms. Genes & Development, 1995, 9(24): 3097-108
[8]  D. Lonmann. Imprinting of the RB1 gene and parent-of-origin effects in retinoblastoma. Medizinische Genetik, 2010, 2: 429- 433.
[9]  L. E. Young, K. Fernandes, T. G. McEvoy, S. C. Butterwith, C. G. Gutierrez, C. Carolan, P. J. Broadben, J. J. Robinson, I. Wilmut and K. D. Sinclair. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nature Genetics, 2001, 27(2): 153-154
[10]  S. Xie, Z. Wang, M. Okano, M. Nogami, Y. Li, W. W. He, K. Okumura and E. Li. Cloning, expression and chromosome loca- tions of the human DNMT3 gene family. Gene, 1999, 236(1): 87- 95.
[11]  D. Lucifero, C. Mertineit, H. J. Clarke, T. H. Bestor and J. M. Trasler. Methylation dynamics of imprinted genes in mouse germ cells. Genomics, 2002, 79(4): 530-538.
[12]  D. Lonmann. Imprinting of the RB1 gene and parent-of-origin effects in retinoblastoma. Medizinische Genetik, 2010, 2: 429- 433.
[13]  P. Bischof, A. Meissue and A. Campana. Mechanisms of endo- metrial control of trophoblast invasion. Journal of Reproductive Fertile Supple, 2000, 55: 65-71.

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