Evaluation of Anti-Arthritic activity of Ethanolic Extract of Cleome rutidosperma

The various extracts of Cleome rutidosperma were investigated for its anti-arthritic activity in male albino rats. The evaluation of anti-arthritic activity was carried out using cotton pellet granulomamethod and Freund’s adjuvant induced arthritis model. Prednisolone (5 mg/kg bw) was used as a standard drug. The ethanolic extract of Cleome rutidosperma exhibited significant anti-arthritic activity as compared to other extracts. The doses of 200 mg/kg bw of the ethanolic extract of Cleome rutidosperma, in chronic model of granuloma pouch in rats produced 48.0% and in arthritis model produced 44.0 % inhibition respectively with that of the standard drug Prednisolone (5 mg/kg) which produced 58.5% and 59% inhibition.