Enhancement of Solubility and Dissolution of Celecoxib by Solid Dispersion Technique

The solid dispersion was defined as the dispersion of one or more active ingredients in an inert carrier or matrix. The purpose of the study was to improve the physicochemical properties of celecoxib like solubility, dissolution properties and stability of poorly soluble drug by forming dispersion with urea as water soluble carrier. The solid dispersion of celecoxib by Physical triturating method, Solvent evaporation and fusion method were prepared using 1:1, 1:3 and 1:5 ratios of drug and polymer (urea). The saturation solubility was carried using USP type XXIV (paddle) type dissolution apparatus. The prepared dispersion showed marked increase in the saturation solubility and dissolution rate of celecoxib than that of pure drug. The dispersion with urea (1:5) by fusion method showed fasterdissolution rate (79.08%) as compared to other dispersions with urea (1:1 and 1:3) whichever prepared by physical mixture and solvent evaporation method. The FT-IR shows the complexation and there were no interactions. Finally solid dispersion of celecoxib: urea prepared as 1:5 ratio by fusion method showed excellent physicochemicalcharacteristics and was found to be described by dissolution release kinetics and was selected as the best formulation in this study.