Design and Development of pH-monitered in situ Gel of Lomefloxacin

Present Study was focused on Design and Development of in situ gel of Lomefloxacin HCL.Lomefloxacin HCL is an antibacterial agent which exhibits rapid precorneal elimination and poor ocular bioavailability, when given in the form of conventional ophthalmic solutions. To overcome this, an attempt has been made to formulate pH-triggered in situ gelling system of Lomefloxacin HCL to provide sustained release of drug based on polymeric carriers that undergo sol-to-gel transition upon change in pH. The Lomefloxacin HCL in situ gelling system formulated by using poly acrylic acid (Carbopol 940) and in combination with hydroxyl propyl methyl cellulose (HPMC) which acted as viscosity enhancing agent. The developed formulation was stable, non-irritant and provided sustained release over 8-hour period and it is a viable alternative to conventional eye drops.