Synthesis and Biological Screening of 3, 4-Dimethoxy benzenesulphonyl Glutamic Acid Analogs as Possible Antineoplastic Agent

As we know that glutamic acid and glutamine are metabolically most reactive amino acids, their possible role in the biosynthesis of DNA and RNA and their structural relevance with thalidomide, cycloheximide and tenuazonic acid, investigations on glutamic acid and glutamine analogs as possible antineoplastic agents were started in our laboratory in the early seventies. In continuation of the above line of work, some derivatives (urides, hydrazides and hydroxamide) of 3,4-Dimethoxybenzenesulphonyl glutamic acid were prepared, characterized and biologically evaluated against Ehrlich Ascites Carcinoma (EAC) cells in Swiss Albino mice in terms of tumor weight and ascitic cell count inhibition as activity parameters using Mitomycin-C as the standard.