Dissolution Enhancement of Mebendazole using by Hupugum

Excipients plays a very important role in the design of dosage forms, because drugs cannot be administered in pure form though there are number of excipients available, need for new excipients with varied characteristics is growing tremendously. Hupugum, a natural polymer was available abundantly in Indian forests. The present investigation is aimed to evaluate the suitability of Hupugum as carrier in the dissolution enhancement of poorly water soluble drug Mebendazole (Anthelmentic). A comparative study on the effect of drug to carrier ratio on dissolution rate was investigated by preparing the solid mixtures containing low and high quantity of Hupugum. Solid mixtures of Mebendazole and Hupugum prepared by physical mixing, co-grinding and kneading methods in the ratio of 10:1,10:2, 1:1,1:5 and 1:7(Mebendazole : Hupugum). Among the ratios used for the preparation, physical mixture showed maximum improvement in dissolution rate of Mebendazole at 1:5 (Mebendazole: Hupugum).