新型基因治疗载体——纳米羟基磷灰石
New Gene Therapy Vector—Nano-Hydroxyapatite

DOI: 10.12677/MS.2013.31003, PP. 11-15

Keywords: 纳米羟基磷灰石；基因治疗载体；转染机制；生物相容性；生物降解性
Nano-Hydroxyapatite, Gene Therapy Vector, Transfection Mechanism, Biocompatibility, Biodegradability

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Abstract:

羟基磷灰石(Hydroxyapatite, Hap)是脊椎动物骨、牙中的天然组分，它具有优异的生物相容性和良好的生物降解性，是目前可通过化学调控大量合成无机生物材料，已被广泛用于硬组织修复材料、药物缓释载体材料等。本文详细综述了近年来纳米羟基磷灰石在基因治疗载体领域的研究进展，阐述了其用于基因治疗载体的转染机制、生物安全性、化学合成的可控性、可降解性及其靶向性等。
Hydroxyapatite (HAp) is the natural inorganic component of vertebrate bone and tooth tissues. It is currently one of the most important inorganic biological materials what can be synthesized by chemical regulation in large amounts. In recent years, owing to its good biocompatibility, excellent biodegradability and chemical synthesis of controllability, it received more and more attention in the application of hard tissue repair materials and drug controlled release vectors. This article reviews its transfection mechanism, biosecurity, controllability of chemical synthesis, biodegradability and targeting used as gene therapy vectors.

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