Preparation, Physico Chemical Characterization of Solid Dispersions of Tenoxicam with Poloxamer

The objective of the present study is to improve the dissolution rate of Tenoxicam, a poorly water soluble drug by solid dispersion technique using a water soluble carrier, poloxamer 127(PXM).The solid dispersions are prepared by melting method and the prepared systems showed an enhancement in dissolution. Solid dispersions are characterized with Differential scanning calorimetry, X-ray diffraction revealed that enhanced dissolution of tenoxicam from solid dispersion is due to a decrease in crystallinity of drug and additive and also due to dissolution of tenoxicam in molten form of solid dispersion. In conclusion preparation of tenoxicam dispersion with meltable hydrophilic polymer could be a promising approach to improve the dissolution rate.