Development of Taste Masked Liquid Formulation of Tinidazole Using Ionexchange resin Complexes

The purpose of this research was to mask the intensely bitter taste of tinidazole (TNZ) and to formulate a palatable liquid formulation of the taste-masked drug, by novel Ion Exchange Resin (IER) method toovercome taste problem with traditional system. Taste masking was done by complexing TNZ with Kyron T-114, Kyron T-134 and Indion 214 in different ratios. Formulation containing resinates were tested for drug content, in vitro drug release, taste masking, stability study, and molecular property. The resinates prepared with drug-Kyron T-134 ratio (1:2) at pH 8, gave maximum drug loading. Suspension containing above resinates showed more than 80% In vitro drug release within 30 min. Prepared formulation also showed good stability and can retain its palatable taste. Thus, the “patientfriendly dosage form” of bitter drugs, especially for pediatric, geriatric, bedridden, and noncooperative patients, can be successfully formulated using this technology.