Assessment of Lipid Profile in Egyptian Children with Chronic Kidney Diseases on Conservative Therapy and Those under Regular Hemodialysis

The present study aimed to evaluate the prevalence and pattern of uremic dyslipidemias in children at different stages of renal impairment and modes of treatment. We studied total cholesterol, triglycerides (Tg), Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) in 28 children with Chronic Kidney Diseases (CKD) on conservative therapy (14 males, 4 females < 10 years old and 7 males and 3 females >= 10 years old) and other 22 children under regular hemodialysis for at least 6 months (13 males and 9 females with median age 12 years). Ten healthy children with age >= 10 years and equal sexes were taken as control. Hypertriglyceridemia and lowered HDL were the characteristic features of uremic dyslipidemia in the majority of hemodialysis children being occurred in 77 and 90.9%, respectively. However, hypertriglceridemia was detected in about 60% of conservative group < 10 years and in about 40% of children >= 10 years and lowered HDL was observed in only 20% of the latter group. We concluded that abnormalities in basic lipid profiles were more frequent in children with CKD under regular hemodialysis than those on conservative therapy and may constitute a major atherogenic risk factor for the development of cardiovascular diseases.