Study of Coating Tablet Extract Noni Fruit(Morinda citrifolia, L.) with Maltodextrin as a Subcoating Material

The present study was carried out to investigate the effect of maltodextrin DE 1-5 from cassava starch as a subcoating material of noni fruit dry extract sugar coating tablets. Maltodextrin were obtained by hydrolysis of cassava starch with Liquezyme EX (α-amylase enzyme from NOVO) at 95 3 C for 2.5-4 min. Noni fruit dry extract was used in core tablets. The core tablets were prepared by wet granulation, then all of the tablets were coated with materials that composed of sucrose, maltodextrin, PEG 6000, CaCO3, TiO2 and distilled water. Core tablets and coated tablets were evaluated in accordance with Indonesian Pharmacopoeia or other pharmaceutical references. Quantitative and qualitative analysis of scopoletine as chemical marker in core and coated tablet has been conducted. Maltodextrin DE 1-5 from cassava starch indicated as coated material compound at noni fruit dry extract sugar coated tablet. The yield of scopoletine in core and coated tablet was 82.91 and 79.61%, respectively. Maltodextrin were potential as coating material in noni fruit dry extract sugar coating tablet and scopoletine as marker compound.