The Use of Induced Pluripotent Stem Cells in Medicine

ABSTRACTInduced pluripotent stem cells with self renewal and differentiation abilities were established from mature cells by transcription factors. These cells may be used in regenerative medicine as embryonic stem cells. Recently a mutated gene in a cell obtained from a mouse which had a genetic disease was corrected by gene targeting techniques. These cells were converted into induced pluripotent stem cell by using transcription factor genes and transferred into the same mouse. As a result, the clinical findings of genetic disease mostly disappeared in the mouse. In this manuscript, the new uses of induced pluripotent stem cells in medicine were discussed.