Novel Excipient for Matrix of Floating Tablet Containing Nile Tilapia Gelatin, Chitosan and Cellulose Derivatives

Floating system has a density lower than the density of the gastric juice. Thus, gastric residence time and hence the bioavailability of drugs that are absorbed in the upper part of the gastrointestinal tract will be improved. Intragastric floating dosage forms are useful for administration of drugs that have a specific absorption site, area insoluble in the intestinal fluid. The aim of this study was to use combination of nile tilapia gelatin, chitosan and ethyl cellulose, methyl cellulose and carboxymethyl cellulose sodium in floating system tablet and to evaluate physical properties and drug release profile of the tablets dosage form. In this study, tablet was formulated by wet granulation method and using diltiazem hydrochloride as a drug model. The swelling and buoyancy of the floating tablets were evaluated. Furthermore, the drug releases from the floating tablets were analyzed using several kinetic models. The result showed that formula containing nile tilapia gelatine and ethyl cellulose at ratio of 1:18 was the best formula which had swelling ratio 16,4% and floating lag time 61 minutes. This formula also revealed a profile of controlled drug release and approached to Higuchi kinetics model and Fickian diffusion mechanism.