The survey of anti-inflammatory effect of bisphosphonates

(Received 13 Dec, 2008 ; Accepted 28 Jan, 2009)AbstractBisphosphonates are currently used in metabolic disorder of bone; however, there have been few studies that reviewed the role of anti-inflammatory and immune modulatory effect of this agent in in-vivo. Bisphosphonates were divided in two classes regarding the structure and mechanism, including amino and non-amino bisphosphonates. The effect of bisphosphonates on cytokine related to in-vitro was complex and related to type and dose of bisphosphonates, examination of cell type and cell culture evaluation system. However, amino bisphosphonates activated inflammatory cytokine regarding to in-vivo and chronic usage of this agent, can stop the production of these cytokines. Present study surveyed the anti -inflammatory and immune modulatory effect of bisphosphonates and clinical trial, along with recent knowledge about potential mechanism of this component.J Mazand Univ Med Sci 2009; 19(69): 79-87 (Persian)