Research on Calcium Phosphate Cement Bone Adhesive

Using citric acid and chitosan as hardening liquid, and calcium phosphate cement (CPC) as powder, gum-like adhesive bone cement is obtained after mixing the powder and liquid components together, which can be used as calcium phosphate cement bone adhesive (CPCBA). The effect of citric acid concentration on compressive strength, setting time and hydration products were investigated. In vitro cytocompatibility of the cements was also researched through cell culture on the cement surface. The results show that setting time is shorten and anti-washout is improved by introducing citric acid. Cohesion strength increases owing to chitosan chelated with calcium ion of CPC. The cements are transformed to hydroxyapatite after incubation 3 d in SBF and osteoblasts (MC3T3-E1) can attach and proliferate on the surface. Results indicate that the calcium phosphate cement bone adhesive is a suitable adhesive material for comminuted fracture.