TNF-α, IL-1β AND IL-8 LEVELS IN TOOTH EARLY LEVELLING MOVEMENT

During orthodontic treatment, the early response of periodontal tissues to mechanical stressinvolves several metabolic changes that allow tooth movement. The aim of the present study was todetermine tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β) and interleukin 8 (IL-8) levelsin GCF in tooth early levelling movement orthodontic treatment.Seventeen patients, 8 female and 9 male individuals (aged: 16-20 years; mean 18.2 ± 1.4years), participated in this study. Each subject underwent a session of professional oral hygieneand received oral hygiene instructions. Three months later, a fixed orthodontic appliance wasplaced. The patients were seen at baseline and between 1-7 days levelling of the teeth.The concentration of TNF-α, IL-1β and IL-8 were shown in Tables 1. There were statisticaldifferences between the observations at the 1-2 day of levelling for TNF-α, IL-1β and IL-8 (p<.05).Orthodontic forced induces rapid release of the TNF-α, 1L-1β and IL 8 levels during toothmovement in gingival crevicular fluid (GCF). The results of this study support the hypothesis thatproinflammatory cytokines play a potent role in bone resorption after the application of orthodonticforce in short time.