AND#945;-Glucosidase and AND#945; -amylase inhibitory activities of Mukia maderaspatana (L) Roem

Aim: The present study is to evaluate the invitro antidiabetic activity of Mukia maderaspatana ethanolic extract and fractions by α-glucosidase and α -amylase inhibitory activity. Methods: Inorder to evaluate if the extraction procedure could influence the activity, we decided to extract with ethanol and fractions with chloroform and n-butanol of Mukia maderaspatana and test each of them with enzyme α-glucosidase and α -amylase inhibitory activity . Results: Mukia maderaspatana ethanolic extract and fractions showed dose dependent inhibition of α-glucosidase and α -amylase enzyme and exhibited lower inhibitory activity than acarbose. Conclusion: The study revealed the antidiabetic potential and could be helpful to develop medicinal preparations and nutraceuticals and function foods for diabetes. [J Intercult Ethnopharmacol 2012; 1(2.000): 97-100]