Study on Hemostatic Materials of Mesoporous Silicon Dioxide Doped Ca and Ag with Antibacterial Properties

An antibacterial hemostatic material of mesoporous silicon oxide gel doped with Ca and Ag (m―SCA) gel was fabricated by using cetyltrimethylammonium bromide(CTAB) as templates and Sol―Gel process. The results showed that m―SCA with mesoporous structure had the surface area of 416 m2/g and pore size of around 2 nm. The m―SCA with high surface area and good clotting function could significantly shorten the prothrombin time (PT) and activated partial thromboplastin time (APTT). The m―SCA containing a small quantity of Ag had no obvious effects on its clotting properties while Ca in m―SCA could promote clotting. The m―SCA doped 0.02wt% Ag without cytotoxicity had good antibacterial properties against E.coli. Animal experimental results showed that the m―SCA could control hemorrhage and shorten the bleeding time of rabbit ear wound, showing good hemostatic properties. It suggestes that the m―SCA is a good hemostatic material with antibacterial properties.