Preparation and Drug Release Properties of Nanostructured CaCO3 Porous Hollow Microspheres

CaCO3 nanostructured porous hollow microspheres were synthesized using CaCl2, Na2CO3, SDS in aqueous solution at room temperature. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscope (TEM) and scanning electron microscope (SEM). The drug loading and release properties of CaCO3 nanostructured porous hollow microspheres were investigated in artificial gastric juice (pH￡ 1.2) and simulated intestinal fluid (pH￡ 7.4). Ibuprofen (IBU) was used as a model drug. The drug delivery system constructed by IBU/CaCO3 porous hollow microspheres exhibits high drug loading capacity and good drug release property. The IBU loading amount reaches 195mg/g and its release time can last for more than 53h. In comparison, the IBU loading amount reaches 130mg/g in thermally treated CaCO3 hollow microspheres in which SDS is eliminated, and the drug release time can reach 40h when IBU release percentage is 100%. The produced CaCO3 nanostructured porous hollow microspheres have the potential application in the sustained drug delivery.a¤