SELF EMULSIFYING DRUG DELIVERY SYSTEM

Drugs are most often administered by the oral route. However, more than 40% of new chemical entities exhibit poor aqueous solubility, resulting in unsatisfactory oral drug delivery. Recently, much attention has been focused on selfemulsifying drug delivery systems (SEEDS) to improve the oral bioavailability of poorly aqueous soluble drugs. SEEDS are isotropic mixtures of oil, surfactants, solvents and co-solvents/surfactants. Self-emulsifying drug delivery systems (SEEDS) are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal tract. The principal characteristic of these systems is their ability to form fine oil-in-water (o/w) emulsions upon mild agitation following dilution by an aqueous phase.SEEDS may be a promising strategy to improve the rate and extent of oral absorption. This article gives an overview of the mechanism of SEEDS, Composition and application of SEEDS.