ISOLATION AND EVALUATION OF BINDING PROPERTY OF ZIZYPHUS JUJUBA LAMK. SEED MUCILAGE IN TABLET FORMULATIONS

The present work reports isolation of seed mucilage of Zizyphus jujuba. Physiochemical characterization such as swelling index, hydration capacity, powder porosity, loss on drying, pH and viscosity were studied. The seed mucilage of Zizyphus jujuba has been evaluated for its granulating and binding properties in tablets, using paracetamol as a model drug. The seed mucilages of Zizyphus jujuba was used in four different concentrations 2.5, 5.0, 7.5 and 10.0%w/v. The granules were prepared by wet granulation technique. The prepared granules were evaluated for percentage of fines, average particle size and flow properties. The properties were compared with guar gum10% w/v. The tablets were prepared and evaluated for hardness, friability, content uniformity, disintegration time and in vitro dissolution profiles. They had good physicochemical properties, and the drug release was more than 80% within 2h. All the formulations (F1, F2, F3, and F4) were subjected to stability studies for three months as per ICH guidelines, only F1 and F4 showed stability with respect to release pattern and other parameters. Hence, 2.5% and 10.0% concentrations of mucilage of Zizyphus jujuba can be considered as ideal concentrations for preparation of tablets.