CARACTERIZACIóN DE LAS REACCIONES ADVERSAS MEDICAMENTOSAS MORTALES. CUBA 2000 - 2008.

Observational, descriptive, retrospective, pharmacovigilance, using the 256 reports of suspected adverse drug reactions that evolved into the patient's death, received from 2000 to 2008 in the National Pharmacovigilance Coordiandora. Were characterized according to age, sex, suspected drugs, drug group and body system affected, causation, frequency and to describe the potential determinants and preventable reactions. Adults were the most affected (47%), with slight female predominance (53%), the drug group contributed more notifications J (44.5%), finding associated mostly crystalline penicillin G (44 notifications). General events (37.5%) were 82 reports of anaphylactic shock, 50.4% of reactions were classified as probable and low frequency. Indications were found unsuitable preventable 15.8% and apparently the use of two or more drugs (58.1%) contributed to the occurrence of adverse drug reactions.