EFECTO DEL TRATAMIENTO CON OXALIPLATINO SOBRE LOS NIVELES DE TIORREDOXINA Y DE LA MOLéCULA IDO (INDOLAMINA 2,3 DIOXIGENASA) EN LINEAS CELULARES DE CáNCER COLORRECTAL.

Increases in indoleamine-2-3-dyoxigenase activity and changes in redox state have been reported in cancer. However, their relationship with chemoterapy remains unknown. The aim of the present study was to evaluate the oxaliplatin treatment in colorectal cancer cell lines (Caco-2 and SW480) on the immunosuppressive molecule IDO and its relationship with the Trx/TrxR system. Results of this study was a higher IDO enzyme activity in Caco-2 cells than in SW480 cells associated with lower levels of the thioredoxin.