FORMULATION DESIGN, DEVELOPMENT AND EVALUATION OF VANCOMYCIN HYDROCHLORIDE TABLETS FOR PSEUDOMEMBRANOUS COLITIS BY DIRECT COMPRESSION METHOD

Conventional dosage form (Tablet) of vancomycin hydrochloride was prepared by direct compression method using Lactose (Direct Compression Lactose-21) as diluent and Avicel 200 as filler disintegrating agent while Kollidon- CL (Crosslinked polyvinyl pyrollidone) was used as superdisintegrant. Tablet prepared by using 10 mm flat punch on single stroke machine. The direct compression method is preferred due to good flow property of powder vancomycin hydrochloride (% Carr’s Index 17.5).The drug release profile of tablets was studies in distilled water because drug is freely soluble in water (1 gm in 10 ml). Formula of vancomycin hydrochloride was optimized by varying % of lubricating agent (Magnesium stearate), disintegrating agent (Kollidon – CL), hardness of tablets. On increasing the % of magnesium stearate drug release is reduced (delay) as well as increasing in the friability, while as % of disintegrating agent is increases, disintegration time is reduced but again friability was increased that was not desirable. Optimum percentage of magnesium stearate was 1% w/w and 1% w/w kollidon-CL was good regarding drug release and other parameters of tablets.