Plasmacytoma cases with unfamiliar clinical features

Plasmacytoma is a relatively rare form of plasma cell dyscrasias with indolent clinical features. Major localizations are in the upper airways and the region of head. Since it represents only a minority of all plasma cell neoplasms, careful histological review should be addressed to the specimens of these patients. In this paper the authors report three cases, developing plasmacytoma with uncommon clinical features. First patient had an unfamiliar localization of plasmacytoma in the cerebellopontine angle which was first meant to be malignant meningioma and later a large subcutaneous mass was detected in the gluteal region. Second patient developed plasmacytoma after a prostate adenocarcinoma as a secondary malignancy. Third patient, developed plasmacytoma and definite plasma cell myeloma with a coexistence of systemic sclerosis. Treating patients with chemo-radiotherapy, and irradiating the one with localized disease resulted in complete remission in two out of the three patients. Imaging techniques such as positron emission tomography combined with computed tomo- graphy (PET-CT) proved to be useful as tumor exploration tool, however multidisciplinary cooperation is recommended in these cases.